Diurnal rhythm and the effect of hemodialysis therapy on blood prolactin levels in patients with chronic renal insufficiency

• Published in: Srpski arhiv za celokupno lekarstvo Vol. 118; no. 9-10; p. 347
• Main Authors: Bolićević, M, Strahinjić, S, Ivić, M, Miljković, P, Stefanović, V
• Format: Journal Article
• Language: Serbian
• Published: Serbia 01.09.1990
• Subjects: Adult; Circadian Rhythm; Female; Humans; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - therapy; Male; Prolactin - blood; Renal Dialysis
• ISSN: 0370-8179

In 97 patients with different stages of chronic renal failure prolactin serum level was determined, and its diurnal rhythm and dependence on haemodialysis treatment were studied. Diurnal rhythm was investigated in 6 men and 6 women with advanced chronic renal failure on diet and other symptomatic treatment. A normal diurnal rhythm of prolactin was recorded only in 3 patients, two of them being with elevated basal prolactin levels; an abnormal prolactin rhythm was documented in 8 patients. In 4 patients no evident diurnal changes in prolactin level were observed, though 3 of them had a normal basal prolactin level. In one patient slight fluctuations of the prolactin level were recorded, while in 4 other patients an abnormal type of diurnal rhythm was observed. Prolactin determinations in patients on maintenance haemodialysis showed increased values in 45 men (719 + 122 mIU/l) as well as 34 women (1251 + 171 mIU/l). The analysis of the influence of haemodialysis on cuprophane and polyacrylonitrile membrane was made in 6 patients and no difference was shown between predialysis and postdialysis serum prolactin values, as well as in values obtained for non-dialysis and dialysis days. The results obtained in this study showed an absent or abnormal diurnal rhythm of prolactin in 75% of patients with chronic renal failure. In patients on maintenance haemodialysis increased prolactin levels were found. Haemodialysis procedure on cuprophane and polyacrylonitrile membrane failed to affect the serum level of prolactin.