Evaluation of ventricular function in patients treated with mitoxantrone and 4'-epidoxorubicin
Serial assessment of ventricular function by means of radionuclide angiography was performed in previously untreated patients with lymphoproliferative diseases who received either 4'epidoxorubicin or mitoxantrone for longer than 6 months. No changes were observed in left ventricular function in...
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Published in | Archivos del Instituto de Cardiologia de Mexico Vol. 59; no. 6; p. 615 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | Spanish |
Published |
Mexico
01.11.1989
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Subjects | |
Online Access | Get more information |
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Summary: | Serial assessment of ventricular function by means of radionuclide angiography was performed in previously untreated patients with lymphoproliferative diseases who received either 4'epidoxorubicin or mitoxantrone for longer than 6 months. No changes were observed in left ventricular function in patients received mitoxantrone at doses ranged 90 to 165 mg (mean 113 mg). Three patients (7%) in 4'epidoxorubicin group showed less than or equal to 10% drop in left ventricular ejection, but without clinical manifestations. The doses in this group were 420 to 810 mg (mean 610 mg). We felt that patients without high-risk factors (radiotherapy to mediastinum or previously anthracycline therapy) could be treated with high doses of both drugs and that radionuclide angiography is a useful method for monitoring cardiotoxicity of antineoplastic drugs. |
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ISSN: | 0020-3785 |