Reaction of acylation of the antineoplastic antibiotic bleomycetin

• Published in: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] Vol. 40; no. 8; p. 7
• Main Authors: Usol'tseva, S V, Andronnikova, G P, Lomakina, N N, Anisimova, T M, Zenkova, V A
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.08.1995
• Subjects: Acylation; Antibiotics, Antineoplastic - chemistry; Bleomycin - analogs & derivatives; Bleomycin - chemistry; Copper - chemistry; Molecular Structure; Spermidine - chemistry

The reaction of benzoylation of bleomycetin, a glycopeptide antibiotic, and its cuprum complex was studied with the chloranhydride and carbodiimide methods. Acylation of the antibiotic cuprum complex by an equivalent quantity of benzoyl chloride resulted in formation of a mixture of mono- and disubs...