Trials of various regimens for using medamine at different stages in the development of Nippostrongylus brasiliensis

Experimental invasion of white outbred mice with Nippostrongylus brasiliensis show, that chemotherapeutic effectiveness of medamin is changing in various developmental stages of this helminth. Larva of the fourth phase is most sensitive to medamin; adult worm, especially in the beginning of oviposit...

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Bibliographic Details
Published inMeditsinskaia parazitologiia i parazitarnye bolezni no. 2; p. 21
Main Authors Rashid, V M, Astaf'ev, B A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.1993
Subjects
Animals
Antinematodal Agents - administration & dosage
Benzimidazoles - administration & dosage
Carbamates
Disease Models, Animal
Drug Evaluation, Preclinical
Larva - drug effects
Larva - growth & development
Mice
Nippostrongylus - drug effects
Nippostrongylus - growth & development
Strongylida Infections - drug therapy
Strongylida Infections - parasitology
Time Factors
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Summary:Experimental invasion of white outbred mice with Nippostrongylus brasiliensis show, that chemotherapeutic effectiveness of medamin is changing in various developmental stages of this helminth. Larva of the fourth phase is most sensitive to medamin; adult worm, especially in the beginning of oviposition, is less sensitive. Chemotherapeutic effect of medamin is increasing with prolongation of therapeutic period, increase of daily doses and degree of its dispersiveness.
ISSN:0025-8326