Specificity of antinuclear autoantibodies in diseases with systemic destruction of connective tissue

By using the fluorescent antibody technique several patterns of antinuclear antibodies (ANA) were detected in the systemic connective tissue diseases, as well as in some other diseases and in healthy donors, depending on the character of nuclear fluorescence. Homogeneous nuclear fluorescence, homoge...

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Bibliographic Details
Published inBiulleten' eksperimental'noi biologii i meditsiny Vol. 84; no. 7; p. 75
Main Authors Shekhonin, B V, Trusov, O A, Butov, Iu S
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.1977
Subjects
Animals
Antibodies, Antinuclear
Antibody Specificity
Collagen Diseases - immunology
Connective Tissue - immunology
Connective Tissue Cells
Fluorescent Antibody Technique
Gastrointestinal Diseases - immunology
Humans
Lung Diseases - immunology
Lupus Erythematosus, Discoid - immunology
Lupus Erythematosus, Systemic - immunology
Mice
Organ Specificity
Rabbits
Rats
Species Specificity
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Summary:By using the fluorescent antibody technique several patterns of antinuclear antibodies (ANA) were detected in the systemic connective tissue diseases, as well as in some other diseases and in healthy donors, depending on the character of nuclear fluorescence. Homogeneous nuclear fluorescence, homogeneous fluorescence free of nucleaolar fluorescence, ring-shaped fluorescence, lumpy fluorescence, selective nuclealar fluorescence, nuclear fluorescence in the form of long fine plexiform bands associated with fluorescence in the nuclear membrane region. The latter ANA pattern was found only in several forms of lupus erythematosus, and this fluorescence was different from the previously reported "reticular" and "filamentous" patterns.
ISSN:0365-9615