TNF-[alpha] Involvement in Insulin Resistance Induced by Experimental Scorpion Envenomation

• Published in: PLoS neglected tropical diseases Vol. 6; no. 7
• Main Authors: Ait-Lounis, Aouatef, Laraba-Djebari, Fatima
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 01.07.2012
• Subjects: Adipose tissue; Animals; Body fat; Chemokines; Cytokines; Glucose; Hyperglycemia; Inflammation; Insulin resistance; Kinases; Musculoskeletal system; R&D; Research & development; Tropical diseases; Tumor necrosis factor-TNF; Algeria; Animals; Cytokines; Scorpions; Protein-Serine-Threonine Kinases; Insulin Resistance; Gene Expression Profiling; Mice; Adipose Tissue; Real-Time Polymerase Chain Reaction; Tumor Necrosis Factor-alpha; Disease Models, Animal; Snake Bites

Background Scorpion venom induces systemic inflammation characterized by an increase in cytokine release and chemokine production. There have been few experimental studies assessing the effects of scorpion venom on adipose tissue function in vivo. Methodology/Principal Findings To study the adipose...