Mutagenicity studies with nitrofurans. I. Mutagenicity of nitrofurylacrylic acid for mammals
Cytogenetic analysis of mouse bone-marrow cells, the dominant lethal test in mice and the cytogenetic analysis of human peripheral lymphocytes in vitro were used to study the mutagenicity of 3-(5-nitro-2-furyl)acrylic acid (5-NFA) for mammals. The bone-marrow cytogenetic analysis was performed in fe...
Saved in:
Published in | Mutation research Vol. 68; no. 4; p. 367 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
01.12.1979
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | Cytogenetic analysis of mouse bone-marrow cells, the dominant lethal test in mice and the cytogenetic analysis of human peripheral lymphocytes in vitro were used to study the mutagenicity of 3-(5-nitro-2-furyl)acrylic acid (5-NFA) for mammals. The bone-marrow cytogenetic analysis was performed in female mice exposed to 5-NFA administered intraperitoneally in single doses of 15--120 mg/kg and in 5 repeated doses of 15 and 30 mg/kg, intragastrically in single doses of 30--240 mg/kg and 5 repeated doses of 30 and 60 mg/kg, and perorally for 12 weeks to 5-NFA concentration of 10, 100 and 1000 mg 5-FNA/1 in drinking water. The bone-marrow analysis was performed in this case after 12 days, 3, 4, 6, 8, 10 and 12 weeks exposure. No increase in chromosome damage attributable to dosing with 5-NFA occurred in any of these experiments. Experiments in which mice were exposed to 5-NFA in drinking water for 12 weeks and then treated with a single i.p. dose of 2 mg of the mutagen TEPA [trix-(1-aziridinyl)phosphine oxide] per kg revealed that, at a concentration of 1000 mg 5-NFA/1, the clastogenic activity of TEPA was reduced to that in untreated animals. The dominant lethal test was performed in male mice exposed to 5-NFA applied intraperitoneally in single doses of 40--120 mg/kg and in 5 repeated doses of 10--30 mg/kg, intragastrically in 5 repeated doses of 20--60 mg/kg, and perorally for 4 weeks in drinking water containing 5-NFA at concentrations of 10, 100, 316 and 1000 mg/l. No significant differences were detected between the exposed and control groups of animals. Experiments in which male mice were exposed to 5-NFA in drinking water and treated after the 4-week exposure to 5-NFA with 1 mg TEPA/kg revealed that a concentration of 1000 mg 5-NFA/1 reduced TEPA-induced dominant lethality to within control values. A reduction in male fertility was observed after the single or repeated 5-NFA doses, but no changes when 5-NFA was applied in drinking water. The cytogenetic analysis of human peripheral lymphocytes exposed in vitro for the last 24 h of culture to concentrations of 1--100 micrograms 5-NFA/Ml did not show any compound-related chromosomal changes. The results of dominant-lethal and bone-marrow cytogenetic studies in mice after consumption of drinking water containing 1000 mg of 5-NFA/1 for 12 weeks and dosed subsequently with TEPA suggests that 5-NFA has some antimutagenic activity. Because none of the studies reported revealed any compound-related genetic activity, the results suggest that 5-NFA is not a chromosome-breaking agent in mammals. |
---|---|
AbstractList | Cytogenetic analysis of mouse bone-marrow cells, the dominant lethal test in mice and the cytogenetic analysis of human peripheral lymphocytes in vitro were used to study the mutagenicity of 3-(5-nitro-2-furyl)acrylic acid (5-NFA) for mammals. The bone-marrow cytogenetic analysis was performed in female mice exposed to 5-NFA administered intraperitoneally in single doses of 15--120 mg/kg and in 5 repeated doses of 15 and 30 mg/kg, intragastrically in single doses of 30--240 mg/kg and 5 repeated doses of 30 and 60 mg/kg, and perorally for 12 weeks to 5-NFA concentration of 10, 100 and 1000 mg 5-FNA/1 in drinking water. The bone-marrow analysis was performed in this case after 12 days, 3, 4, 6, 8, 10 and 12 weeks exposure. No increase in chromosome damage attributable to dosing with 5-NFA occurred in any of these experiments. Experiments in which mice were exposed to 5-NFA in drinking water for 12 weeks and then treated with a single i.p. dose of 2 mg of the mutagen TEPA [trix-(1-aziridinyl)phosphine oxide] per kg revealed that, at a concentration of 1000 mg 5-NFA/1, the clastogenic activity of TEPA was reduced to that in untreated animals. The dominant lethal test was performed in male mice exposed to 5-NFA applied intraperitoneally in single doses of 40--120 mg/kg and in 5 repeated doses of 10--30 mg/kg, intragastrically in 5 repeated doses of 20--60 mg/kg, and perorally for 4 weeks in drinking water containing 5-NFA at concentrations of 10, 100, 316 and 1000 mg/l. No significant differences were detected between the exposed and control groups of animals. Experiments in which male mice were exposed to 5-NFA in drinking water and treated after the 4-week exposure to 5-NFA with 1 mg TEPA/kg revealed that a concentration of 1000 mg 5-NFA/1 reduced TEPA-induced dominant lethality to within control values. A reduction in male fertility was observed after the single or repeated 5-NFA doses, but no changes when 5-NFA was applied in drinking water. The cytogenetic analysis of human peripheral lymphocytes exposed in vitro for the last 24 h of culture to concentrations of 1--100 micrograms 5-NFA/Ml did not show any compound-related chromosomal changes. The results of dominant-lethal and bone-marrow cytogenetic studies in mice after consumption of drinking water containing 1000 mg of 5-NFA/1 for 12 weeks and dosed subsequently with TEPA suggests that 5-NFA has some antimutagenic activity. Because none of the studies reported revealed any compound-related genetic activity, the results suggest that 5-NFA is not a chromosome-breaking agent in mammals. |
Author | Rössner, P Srám, R J Kodýtková, I Zhurkov, V S |
Author_xml | – sequence: 1 givenname: R J surname: Srám fullname: Srám, R J – sequence: 2 givenname: P surname: Rössner fullname: Rössner, P – sequence: 3 givenname: V S surname: Zhurkov fullname: Zhurkov, V S – sequence: 4 givenname: I surname: Kodýtková fullname: Kodýtková, I |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/522884$$D View this record in MEDLINE/PubMed |
BookMark | eNpVT8lqwzAU1CFNm6V_0IN-wEF-kizlWEKXQEovORbCs5ZWJZaNZFP89zWkBArDDMwMA7Mks9hGNyMLxkAVsmTqjixz_maMiW21vSVzCaC1WJCPt6HHTxeDCf1Icz_Y4DL9Cf0XjaFPrR8Sxryh-w3912z9NR_PaCYKhqIJlvo20QabBs95TW78JO7-T1fk-Px03L0Wh_eX_e7xUHQSROE0GvCiRqgk80ZLbYFrP1kCLZMcmKtLrkruFBoFfAK3KGowitnKVLAiD5fZbqgbZ09dCg2m8XT5CL_vKk_C |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
DatabaseTitleList | MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Chemistry Biology |
ExternalDocumentID | 522884 |
Genre | Journal Article |
GroupedDBID | -~X .55 .GJ 1~5 4G. 53G 5RE 7-5 AAKOC AAQXK ACNCT ADMUD ALMA_UNASSIGNED_HOLDINGS CGR CUY CVF ECM EIF F3I F5P FDB G-2 H~9 IH2 NPM R2- RIG ROL SBG X7M ZGI ZXP ~02 |
ID | FETCH-LOGICAL-p524-e8ac2f4ba2650fc858d238f2f44ad05320eb13713e7ac7237233da4b2c70d6c62 |
ISSN | 0027-5107 |
IngestDate | Sat Sep 28 07:10:27 EDT 2024 |
IsPeerReviewed | false |
IsScholarly | false |
Issue | 4 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-p524-e8ac2f4ba2650fc858d238f2f44ad05320eb13713e7ac7237233da4b2c70d6c62 |
PMID | 522884 |
ParticipantIDs | pubmed_primary_522884 |
PublicationCentury | 1900 |
PublicationDate | 1979-Dec |
PublicationDateYYYYMMDD | 1979-12-01 |
PublicationDate_xml | – month: 12 year: 1979 text: 1979-Dec |
PublicationDecade | 1970 |
PublicationPlace | Netherlands |
PublicationPlace_xml | – name: Netherlands |
PublicationTitle | Mutation research |
PublicationTitleAlternate | Mutat Res |
PublicationYear | 1979 |
SSID | ssj0004969 |
Score | 1.187518 |
Snippet | Cytogenetic analysis of mouse bone-marrow cells, the dominant lethal test in mice and the cytogenetic analysis of human peripheral lymphocytes in vitro were... |
SourceID | pubmed |
SourceType | Index Database |
StartPage | 367 |
SubjectTerms | Acrylates - pharmacology Animals Body Weight - drug effects Bone Marrow - drug effects Bone Marrow - physiology Chromosome Aberrations - drug effects Drinking Behavior - drug effects Female Genes, Dominant Genes, Lethal Humans Lymphocytes - drug effects Lymphocytes - physiology Male Mice Mutation - drug effects Nitrofurans - pharmacology |
Title | Mutagenicity studies with nitrofurans. I. Mutagenicity of nitrofurylacrylic acid for mammals |
URI | https://www.ncbi.nlm.nih.gov/pubmed/522884 |
Volume | 68 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ3rS8MwEMCD84H7IjoV3-SD30bH2qZN9lGn4gP9oBOGCJImKYrugW6C_vVect1an6gwwrikpesvu16udzlCtjUPQe8nqce4Vh4zYcOTEVOerxkXLBGmjlG-Z_HhJTtuR-28KqrLLhkkNfX6ZV7Jf6iCDLjaLNk_kB2fFATwHfhCC4Sh_RXj0-EA1EH3TllT-gkjAtGzCn9UULBD9yCqHtWq70ba2I2s_-VBKmjspq3qTruYw47sdOTDU9FqtUe7eZJtDTR2IV_gi3YfayXnr5jOrXg3Bv2CM2KcRHZ1O3y87z276Nrc63rS0-6AvYHtc2fMHboac_R4oxDeMUoR4F6UlbMdqdlYFKYTK-jMEOtxFHj1Ow4YmIYC68f91Pdhu2zsKJESF1bhnVnnzShNthFnET94dWUyjaM_LCmcadGaJ3PZmoDuIOAFMmG6FTKDVUJfKmS2OSrKt0iuiyBphpxa5LSInB7V6LuRvZR-Qk4tcgrIaYZ8ibQO9lvNQy8rkOH1o4B5RkgVpCyRAZjZqRKR0GCApSBiUruKH_AgDrkfGi4VD0L4hFqyJFC8rmMVB8tkstvrmhVChc-NqusUFsySsVAIw_y6MUyzqKEiLVbJEt6hmz5ugnKDd27tG_k6KecTY4NMpfAjzCaYb4Nky0F5A5XuSAI |
link.rule.ids | 786 |
linkProvider | National Library of Medicine |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mutagenicity+studies+with+nitrofurans.+I.+Mutagenicity+of+nitrofurylacrylic+acid+for+mammals&rft.jtitle=Mutation+research&rft.au=Sr%C3%A1m%2C+R+J&rft.au=R%C3%B6ssner%2C+P&rft.au=Zhurkov%2C+V+S&rft.au=Kod%C3%BDtkov%C3%A1%2C+I&rft.date=1979-12-01&rft.issn=0027-5107&rft.volume=68&rft.issue=4&rft.spage=367&rft_id=info%3Apmid%2F522884&rft_id=info%3Apmid%2F522884&rft.externalDocID=522884 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0027-5107&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0027-5107&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0027-5107&client=summon |