Effect of magnesium ions on heat denaturation of DNA

• Published in: Molekuliarnaia biologiia Vol. 11; no. 4; p. 748
• Main Authors: Blagoĭ, Iu P, Sorokin, V A, Valeev, V A, Khomenko, S A, Gladchenko, G O
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.07.1977
• Subjects: DNA; Dose-Response Relationship, Drug; Hot Temperature; Magnesium - pharmacology; Nucleic Acid Denaturation - drug effects; Thermodynamics

The dependence of animal DNA denaturation on magnesium ion concentration has been studied in the range (10(-6)--10(-1) M with sodium ion content of 10(-3) and 10(-2) M. Special attention has been given to the effect of multivalent metallic impurities bound to DNA. An increase of DNA thermal stabilit...