Effect of some fragments of peptide hormones on the content of biogenic monoamines from mouse brain

The effect of some tripeptides, which are fragments of peptide hormones, and their analogs on the content of biogenic monoamines (BM) from albino mice brain was studied. It was found that thyroliberin, melanostatin and the C-terminal tripeptide of gonadoliberin activate the dophaminergic (DA-ergic)...

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Bibliographic Details
Published inBiokhimiia (Moscow, Russia) Vol. 44; no. 1; p. 93
Main Authors Zile, R K, Odynets, T G, Klusha, V E
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.1979
Subjects
Animals
Biogenic Amines - metabolism
Brain - drug effects
Brain - metabolism
Gastrins - pharmacology
Gonadotropin-Releasing Hormone - pharmacology
Hormones - pharmacology
Mice
MSH Release-Inhibiting Hormone - pharmacology
Oligopeptides - pharmacology
Receptors, Dopamine - drug effects
Structure-Activity Relationship
Thyrotropin-Releasing Hormone - pharmacology
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Summary:The effect of some tripeptides, which are fragments of peptide hormones, and their analogs on the content of biogenic monoamines (BM) from albino mice brain was studied. It was found that thyroliberin, melanostatin and the C-terminal tripeptide of gonadoliberin activate the dophaminergic (DA-ergic) system in the forebrain of mice treated with reserpine or haloperidol, whereas the C-terminal tripeptide of gastrin acts as a synergic blocker of the DA receptors. The N-terminal tripeptides (with and without the amido group) do not affect the content of BM. No effect of the tripeptides was observed in intact animals. It is assumed that the agonistic or antagonistic effect of the tripeptides on BM is due to certain structural peculiarities of the tripeptides, e.g. the presence of the C-terminal amido group and their endogenous nature.
ISSN:0320-9725