Lipid acquisition by intracellular Chlamydiae

Summary Chlamydia species are obligate intracellular pathogens that are important causes of human genital tract, ocular and respiratory infections. The bacteria replicate within a specialized membrane‐bound compartment termed the inclusion and require host‐derived lipids for intracellular growth and...

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Published inCellular microbiology Vol. 14; no. 7; pp. 1010 - 1018
Main Authors Elwell, Cherilyn A., Engel, Joanne N.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.07.2012
Hindawi Limited
Subjects
Chlamydia
Chlamydia - growth & development
Chlamydia - metabolism
Genital tract
Humans
Inclusion Bodies - microbiology
Infection
Lipid Metabolism
Lipids
Pathogens
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Summary:Summary Chlamydia species are obligate intracellular pathogens that are important causes of human genital tract, ocular and respiratory infections. The bacteria replicate within a specialized membrane‐bound compartment termed the inclusion and require host‐derived lipids for intracellular growth and development. Emerging evidence indicates that Chlamydia has evolved clever strategies to fulfil its lipid needs by interacting with multiple host cell compartments and redirecting trafficking pathways to its intracellular niche. In this review, we highlight recent findings that have significantly expanded our understanding of how Chlamydia exploit lipid trafficking pathways to ensure the survival of this important human pathogen.
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ISSN:1462-5814
1462-5822
DOI:10.1111/j.1462-5822.2012.01794.x