Effects of high‐dose statin on the human hepatic expression of genes involved in carbohydrate and triglyceride metabolism

• Published in: Journal of internal medicine Vol. 269; no. 3; pp. 333 - 339
• Main Authors: Pramfalk, C., Parini, P., Gustafsson, U., Sahlin, S., Eriksson, M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.03.2011; Blackwell
• Subjects: Adult; Aged; angiopoietin‐like protein 3; Atorvastatin; Atorvastatin Calcium; Biological and medical sciences; Blood Glucose - metabolism; C-Peptide - blood; Carbohydrate metabolism; Carbohydrates; Carbohydrates - blood; Cholesterol; Drug Administration Schedule; Enzymes; Female; Gene expression; Gene Expression Regulation - drug effects; General aspects; Glucokinase; Glucose; Heptanoic Acids - pharmacology; Hospitals; Humans; Hydroxymethylglutaryl-CoA reductase; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; Insulin; Insulin - blood; Lipids; Lipids - blood; Lipoproteins; Lipoproteins (very low density); liver; Liver - drug effects; Liver - metabolism; Male; Medical sciences; Metabolism; Middle Aged; Nutrition; Plasma levels; Pyrroles - pharmacology; Reverse Transcriptase Polymerase Chain Reaction - methods; SREBP1c; statins; Triglycerides; Triglycerides - blood; Angiopoietin; Liver; angiopoietin-like protein 3; Lipids; Hypocholesterolemic agent; Gene; HMG-CoA reductase inhibitor; SREBP1c; Genetics; Carbohydrate; High dose; Human; Digestive system; Enzyme; Enzyme inhibitor; Statin derivative; triglycerides; Metabolism; Triglyceride; Protein; Medicine; Atorvastatin; Hydroxymethylglutaryl-CoA reductase; Oxidoreductases; Antilipemic agent

.  Pramfalk C, Parini P, Gustafsson U, Sahlin S, Eriksson M (Department of Laboratory Medicine, Division of Clinical Chemistry; Department of Biosciences and Nutrition, Centre for Nutrition and Toxicology, Molecular Nutrition Unit, NOVUM; Department of Surgery, Karolinska Institutet at Danderyd Hosp...