Effects of CCK2 receptor blockade on growth parameters in gastrointestinal tract and pancreas in rats

• Published in: Pharmacology & toxicology Vol. 89; no. 4; p. 208
• Main Authors: Björkqvist, M, Norlén, P, Kitano, M, Chen, D, Zhao, C M, de la Cour, C D, Gagnemo-Persson, C, Håkanson, R
• Format: Journal Article
• Language: English
• Published: Denmark 01.10.2001
• Subjects: Animals; Benzodiazepines - toxicity; Benzodiazepinones - toxicity; Digestive System - drug effects; Digestive System - pathology; Drug Interactions; Gastrins - blood; Hormone Antagonists - toxicity; Hyperplasia - chemically induced; Hyperplasia - pathology; Hypertrophy - chemically induced; Hypertrophy - pathology; Male; Omeprazole - pharmacology; Pancreas - drug effects; Pancreas - pathology; Parietal Cells, Gastric - drug effects; Parietal Cells, Gastric - pathology; Phenylurea Compounds - toxicity; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin - antagonists & inhibitors

Gastrin has a growth-promoting effect on the oxyntic mucosa of the stomach but has been claimed also to affect other parts of the gastrointestinal tract and pancreas. This report describes the effects of the cholecystokinin, (CCK2) receptor antagonists YM022 and YF476 on various growth parameters in...