Splenic metabolic activity predicts risk of future cardiovascular events: demonstration of a cardiosplenic axis in humans

• Published in: JACC. Cardiovascular imaging Vol. 8; no. 2; pp. 121 - 130
• Main Authors: Emami, Hamed, Singh, Parmanand, MacNabb, Megan, Vucic, Esad, Lavender, Zachary, Rudd, James H F, Fayad, Zahi A, Lehrer-Graiwer, Joshua, Korsgren, Magnus, Figueroa, Amparo L, Fredrickson, Jill, Rubin, Barry, Hoffmann, Udo, Truong, Quynh A, Min, James K, Baruch, Amos, Nasir, Khurram, Nahrendorf, Matthias, Tawakol, Ahmed
• Format: Journal Article
• Language: English
• Published: United States 01.02.2015
• Subjects: Adult; Aged; Arteritis - diagnostic imaging; Basic Medicine; C-Reactive Protein - metabolism; Disease Progression; Farmakologi och toxikologi; Female; Fluorodeoxyglucose F18; Follow-Up Studies; Humans; Läkemedelskemi; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinal Chemistry; Medicinska och farmaceutiska grundvetenskaper; Middle Aged; Multimodal Imaging - methods; Pharmacology and Toxicology; Positron-Emission Tomography - methods; Predictive Value of Tests; Prognosis; Prospective Studies; Radiopharmaceuticals; Risk Assessment - methods; Risk Factors; Spleen - metabolism; Time Factors; Vascular Calcification - diagnostic imaging; atherosclerosis; FDG; acute coronary syndrome; inflammation; spleen; events

This study sought to determine whether splenic activation after acute coronary syndrome (ACS) is linked to leukocyte proinflammatory remodeling and whether splenic activity independently predicts the risk of cardiovascular disease (CVD) events. Pre-clinical data suggest the existence of a cardiosple...