Cerebrospinal fluid tau and amyloid-β1-42 in patients with dementia

• Published in: Brain (London, England : 1878) Vol. 138; no. Pt 9; pp. 2716 - 2731
• Main Authors: Skillbäck, Tobias, Farahmand, Bahman Y, Rosén, Christoffer, Mattsson, Niklas, Nägga, Katarina, Kilander, Lena, Religa, Dorota, Wimo, Anders, Winblad, Bengt, Schott, Jonathan M, Blennow, Kaj, Eriksdotter, Maria, Zetterberg, Henrik
• Format: Journal Article
• Language: English
• Published: England 01.09.2015
• Subjects: Aged; Amyloid beta-Peptides - cerebrospinal fluid; Analysis of Variance; Clinical Medicine; Dementia - cerebrospinal fluid; Enzyme-Linked Immunosorbent Assay; Female; Humans; Klinisk medicin; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Mental Status Schedule; Middle Aged; Neurologi; Neurology; Neurosciences; Neurovetenskaper; Peptide Fragments - cerebrospinal fluid; Retrospective Studies; Severity of Illness Index; Sweden; tau Proteins - cerebrospinal fluid; Sweden; dementia with Lewy bodies; frontotemporal dementia; Alzheimer’s disease; biomarkers; vascular dementia

Progressive cognitive decline in combination with a cerebrospinal fluid biomarker pattern of low levels of amyloid-β1-42 and high levels of total tau and phosphorylated tau is typical of Alzheimer's disease. However, several neurodegenerative disorders may overlap with Alzheimer's disease...