Post‐Transcriptional Regulation of the Human Mu‐Opioid Receptor (MOR) by Morphine‐Induced RNA Binding Proteins hnRNP K and PCBP1

• Published in: Journal of cellular physiology Vol. 232; no. 3; pp. 576 - 584
• Main Authors: Song, Kyu Young, Choi, Hack Sun, Law, Ping‐Yee, Wei, Li‐Na, Loh, Horace H.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2017
• Subjects: 5' Untranslated Regions; 5' Untranslated Regions - genetics; Animals; Binding sites; Cell Line, Tumor; Gene expression; Gene Expression Regulation - drug effects; Gene regulation; Heterogeneous-Nuclear Ribonucleoprotein K - genetics; Heterogeneous-Nuclear Ribonucleoprotein K - metabolism; Heterogeneous-Nuclear Ribonucleoproteins - genetics; Heterogeneous-Nuclear Ribonucleoproteins - metabolism; hnRNA; Humans; Immunoprecipitation; Mice; Morphine; Morphine - pharmacology; Narcotics; Neuroblastoma; Opioid receptors (type mu); Poly(C)-binding protein; Polyribosomes - drug effects; Polyribosomes - metabolism; Post-transcription; Protein Binding - drug effects; Proteins; Receptors, Opioid, mu - genetics; Receptors, Opioid, mu - metabolism; Ribonucleic acid; RNA; RNA, Messenger - genetics; RNA, Messenger - metabolism; RNA-binding protein; Stimulation; Transcription; Transcription, Genetic - drug effects; Up-Regulation - drug effects; Up-Regulation - genetics

Expression of the mu‐opioid receptor (MOR) protein is controlled by extensive transcriptional and post‐transcriptional processing. MOR gene expression has previously been shown to be altered by a post‐transcriptional mechanism involving the MOR mRNA untranslated region (UTR). Here, we demonstrate fo...