Crystal structure of the FK506 binding domain of human FKBP25 in complex with FK506

Human FKBP25 (hFKBP25) is a nuclear immunophilin and interacts with several nuclear proteins, hence involving in many nuclear events. Similar to other FKBPs, FK506 binding domain (FKBD) of hFKBP25 also binds to immunosuppressive drugs such as rapamycin and FK506, albeit with a lower affinity for the...

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Bibliographic Details
Published inProtein science Vol. 25; no. 4; pp. 905 - 910
Main Authors Prakash, Ajit, Rajan, Sreekanth, Yoon, Ho Sup
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.04.2016
John Wiley and Sons Inc
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