Ubiquitin‐specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling

• Published in: The EMBO journal Vol. 37; no. 20
• Main Authors: Guo, Yu‐chen, Wang, Meng‐yuan, Zhang, Shi‐wen, Wu, Yun‐shu, Zhou, Chen‐chen, Zheng, Ri‐xin, Shao, Bin, Wang, Yuan, Xie, Liang, Liu, Wei‐qing, Sun, Ning‐yuan, Jing, Jun‐jun, Ye, Ling, Chen, Qian‐ming, Yuan, Quan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.10.2018; Springer Nature B.V; John Wiley and Sons Inc
• Subjects: Biocompatibility; Biodegradation; Biomedical materials; bone formation; Bone growth; Bone mass; Bone morphogenetic protein 2; Cbfa-1 protein; Clonal deletion; Depletion; Differentiation (biology); EMBO11; EMBO31; EMBO37; In vivo methods and tests; Mesenchymal stem cells; Mesenchyme; Mice; Osteoblastogenesis; Osteoblasts; Osteogenesis; osteogenic differentiation; Protease; Proteinase; Proteins; Regeneration; Regeneration (physiology); Signaling; Stem cell transplantation; Stem cells; Ubiquitin; Ubiquitin-protein ligase; ubiquitin‐specific protease 34; bone formation; ubiquitin‐specific protease 34; mesenchymal stem cells; osteogenic differentiation

The osteogenic differentiation of mesenchymal stem cells (MSCs) is governed by multiple mechanisms. Growing evidence indicates that ubiquitin‐dependent protein degradation is critical for the differentiation of MSCs and bone formation; however, the function of ubiquitin‐specific proteases, the large...