Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16

• Published in: EMBO reports Vol. 19; no. 10
• Main Authors: Wang, Pei‐Hui, Ye, Zi‐Wei, Deng, Jian‐Jun, Siu, Kam‐Leung, Gao, Wei‐Wei, Chaudhary, Vidyanath, Cheng, Yun, Fung, Sin‐Yee, Yuen, Kit‐San, Ho, Ting‐Hin, Chan, Ching‐Ping, Zhang, Yan, Kok, Kin‐Hang, Yang, Wanling, Chan, Chi‐Ping, Jin, Dong‐Yan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2018; Springer Nature B.V; John Wiley and Sons Inc
• Subjects: Activation; AIM2; Animals; Autoimmune diseases; Cell Nucleus - genetics; Complex formation; Cytoplasm; DNA - genetics; DNA-Binding Proteins - antagonists & inhibitors; DNA-Binding Proteins - genetics; Double-stranded RNA; EMBO19; EMBO23; EMBO37; Gene Expression Regulation; Gene Knockdown Techniques; Homology; Human tissues; Humans; IFI16; inflammasome; Inflammasomes; Inflammasomes - genetics; Interferon; Interleukin-1beta - genetics; Interleukins; Intracellular Signaling Peptides and Proteins - genetics; Leukocytes; Mice; Nuclear Proteins - genetics; Phosphoproteins - genetics; Protein Isoforms - genetics; Pyrin protein; RNA, Double-Stranded - genetics; RNA, Messenger - genetics; transcript isoform; Transcription; Viruses; AIM2; IFI16; transcript isoform; inflammasome

Mouse p202 is a disease locus for lupus and a dominant‐negative inhibitor of AIM2 inflammasome activation. A human homolog of p202 has not been identified so far. Here, we report a novel transcript isoform of human IFI16‐designated IFI16‐β, which has a domain architecture similar to that of mouse p2...