SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer - Chen, Xiu‐Fei; Tian, Meng‐Xin; Sun, Ren‐Qiang; Zhang, Meng‐Li; Zhou, Li‐Sha; Jin, Lei; Chen, Lei‐Lei; Zhou, Wen‐Jie; Duan, Kun‐Long; Chen, Yu‐Jia; Gao, Chao; Cheng, Zhou‐Li; et al. (EMBO reports, 2018)
Keywords: ACOX1; Acyl-CoA Oxidase - antagonists & inhibitors; Acyl-CoA Oxidase - genetics; Acyl-CoA Oxidase - metabolism; Animals; Carcinoma, Hepatocellular - metabolism; Clonal deletion; Damage prevention; Deoxyribonucleic acid; Dimers; DNA; DNA Damage; Down-Regulation; EMBO03; EMBO29; EMBO31; Female; Gene Knockdown Techniques; HEK293 Cells; HeLa Cells; Hep G2 Cells; Hepatocellular carcinoma; Homeostasis; Humans; Hydrogen Peroxide; Liver; Liver cancer; Liver Neoplasms - metabolism; Male; Metabolism; Mice; Mice, Knockout; Middle Aged; Oxidation; Oxidation-Reduction; Oxidative Stress; Peroxisomes; Peroxisomes - chemistry; Prognosis; Reactive oxygen species; SIRT5; Sirtuins - genetics; Sirtuins - metabolism; succinylation; SIRT5; liver cancer; succinylation; ACOX1; oxidative stress