Tanshinone IIA alleviates lipopolysaccharide‐induced acute lung injury by downregulating TRPM7 and pro‐inflammatory factors

• Published in: Journal of cellular and molecular medicine Vol. 22; no. 1; pp. 646 - 654
• Main Authors: Li, Jie, Zheng, Yan, Li, Ming‐Xian, Yang, Chu‐Wei, Liu, Yu‐Fei
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.01.2018; John Wiley and Sons Inc
• Subjects: Abietanes - pharmacology; Abietanes - therapeutic use; acute lung injury; Acute Lung Injury - chemically induced; Acute Lung Injury - drug therapy; Acute Lung Injury - metabolism; Acute Lung Injury - pathology; Animals; Calcium; Calcium - metabolism; Calcium channels (voltage-gated); Calcium imaging; Calcium influx; Cell density; Down-Regulation; Enzyme-linked immunosorbent assay; Inflammation; Inflammation Mediators - metabolism; Interleukin 1; Interleukin 6; Interleukin-1beta - metabolism; Interleukin-6 - metabolism; lipopolysaccharide; Lipopolysaccharides; Lung - drug effects; Lung - pathology; Lungs; Macrophages - drug effects; Macrophages - metabolism; Male; Organ Size; Original; Oxygen - metabolism; Partial Pressure; Protein expression; Proteins; Rats; Rats, Wistar; Rodents; Serous Membrane - pathology; Tanshinone IIA; transient receptor potential melastatin 7; Transient receptor potential proteins; TRPM Cation Channels - metabolism; Tumor necrosis factor; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumors; tumour necrosis factor alpha; Western blotting; Tanshinone IIA; interleukin 6; transient receptor potential melastatin 7; lipopolysaccharide; acute lung injury; tumour necrosis factor alpha

The study aimed to investigate the role of Tanshinone IIA (Tan IIA) in lipopolysaccharide (LPS)‐induced acute lung injury (ALI) in its regulation of TRPM7. Wistar male rats were randomly divided into the normal saline (NS), LPS, knockout (KO) + LPS, low‐dose Tan IIA (Tan‐L), middle‐dose Tan IIA (Tan...