A CD8α− Subset of CD4+SLAMF7+ Cytotoxic T Cells Is Expanded in Patients With IgG4‐Related Disease and Decreases Following Glucocorticoid Treatment

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 70; no. 7; pp. 1133 - 1143
• Main Authors: Della‐Torre, Emanuel, Bozzalla‐Cassione, Emanuele, Sciorati, Clara, Ruggiero, Eliana, Lanzillotta, Marco, Bonfiglio, Silvia, Mattoo, Hamid, Perugino, Cory A., Bozzolo, Enrica, Rovati, Lucrezia, Arcidiacono, Paolo Giorgio, Balzano, Gianpaolo, Lazarevic, Dejan, Bonini, Chiara, Falconi, Massimo, Stone, John H., Dagna, Lorenzo, Pillai, Shiv, Manfredi, Angelo A.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2018
• Subjects: CD4 antigen; CD45RA antigen; Cell activation; Cytotoxicity; Effector cells; Flow cytometry; Gene sequencing; Glucocorticoids; Immunoglobulin G; Lymphocytes; Lymphocytes T; Medical treatment; Memory cells; Molecular chains; Patients; Perforin; Peripheral blood; Remission; T cell receptors

Objective An unconventional population of CD4+ signaling lymphocytic activation molecule family member 7–positive (SLAMF7+) cytotoxic effector memory T (TEM) cells (CD4+ cytotoxic T lymphocytes [CTLs]) has been linked causally to IgG4‐related disease (IgG4‐RD). Glucocorticoids represent the first‐li...