Predictors of CD4 cell recovery following initiation of antiretroviral therapy among HIV‐1 positive patients with well‐estimated dates of seroconversion

• Published in: HIV medicine Vol. 19; no. 3; pp. 184 - 194
• Main Authors: Stirrup, OT, Copas, AJ, Phillips, AN, Gill, MJ, Geskus, RB, Touloumi, G, Young, J, Bucher, HC, Babiker, AG, Kelleher, Tony, Cooper, David, Grey, Pat, Finlayson, Robert, Bloch, Mark, Ramacciotti, Tim, Gelgor, Linda, Smith, Don, Zangerle, Robert, Gill, John, Lutsar, Irja, Chêne, Geneviève, Dabis, Francois, Thiebaut, Rodolphe, Costagliola, Dominique, Guiguet, Marguerite, Vanhems, Philippe, Chaix, Marie‐Laure, Ghosn, Jade, Meyer, Laurence, Boufassa, Faroudy, Hamouda, Osamah, Meixenberger, Karolin, Bannert, Norbert, Bartmeyer, Barbara, Antoniadou, Anastasia, Chrysos, Georgios, Daikos, Georgios L., Pantazis, Nikos, Katsarou, Olga, Rezza, Giovanni, Dorrucci, Maria, Monforte, Antonella, Luca, Andrea, Prins, Maria, Geskus, Ronald, Helm, Jannie, Schuitemaker, Hanneke, Sannes, Mette, Brubakk, Oddbjorn, Kran, Anne‐Marte, Rosinska, Magdalena, Muga, Roberto, Tor, Jordi, Olalla, Patricia, Cayla, Joan, Amo, Julia, Moreno, Santiago, Monge, Susana, Romero, Jorge, Pérez‐Hoyos, Santiago, Sönnerborg, Anders, Bucher, C, Günthard, Huldrych, Scherrer, Alexandra, Malyuta, Ruslan, Murphy, Gary, Porter, Kholoud, Johnson, Anne, Babiker, Abdel, Pillay, Deenan, Morrison, Charles, Salata, Robert, Mugerwa, Roy, Chipato, Tsungai, Price, Matt A., Gilmour, Jill, Kamali, Anatoli, Karita, Etienne
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.03.2018; John Wiley and Sons Inc
• Subjects: Acquired immune deficiency syndrome; AIDS; Anti-HIV Agents - therapeutic use; Antiretroviral agents; Antiretroviral drugs; Antiretroviral therapy; CD4; CD4 antigen; CD4 Lymphocyte Count; Drug therapy; Female; HAART; HIV; HIV Infections - drug therapy; HIV Infections - immunology; HIV-1 - immunology; Human immunodeficiency virus; Humans; longitudinal data; Male; Mathematical models; mixed effects model; Models, Statistical; Original Research; Patients; Seroconversion; Statistical analysis; Statistical models; Therapy; Treatment Outcome; Viral Load; CD4; ART; HIV; antiretroviral therapy; HAART; longitudinal data; mixed effects model

Objectives To investigate factors that predict speed of recovery and long‐term CD4 cell count in HIV‐1 seroconverters initiating combination antiretroviral therapy (cART), and to quantify the influence of very early treatment initiation. We make use of all pre‐treatment CD4 counts, because analyses...