Infiltrating cellular pattern in kidney graft biopsies translates into forkhead box protein 3 up‐regulation and p16INK4α senescence protein down‐regulation in patients treated with belatacept compared to cyclosporin A

• Published in: Clinical and experimental immunology Vol. 167; no. 2; pp. 330 - 337
• Main Authors: Furuzawa‐Carballeda, J., Lima, G., Alberú, J., Palafox, D., Uribe‐Uribe, N., Morales‐Buenrostro, L. E., Reyes Acevedo, R., Mondragón, G., Chevaile, A., Llorente, L.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2012; Blackwell; Blackwell Science Inc
• Subjects: Abatacept; Adrenal Cortex Hormones - therapeutic use; Adult; Analytical, structural and metabolic biochemistry; Antibodies, Monoclonal - therapeutic use; belatacept; Biological and medical sciences; Biopsy; CD4 antigen; Cell survival; Cellular Senescence - drug effects; Clinical Trials, Phase III as Topic - statistics & numerical data; Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis; Cyclosporin A; Cyclosporine - pharmacology; Cyclosporine - therapeutic use; Double-Blind Method; Down-Regulation - drug effects; Female; Fibrosis; Forkhead protein; Forkhead Transcription Factors - biosynthesis; Forkhead Transcription Factors - genetics; Foxp3 protein; FoxP3+ expressing cells; Fundamental and applied biological sciences. Psychology; Genes, p16; Graft rejection; Humans; Immunoconjugates - pharmacology; Immunoconjugates - therapeutic use; Immunohistochemistry; Immunological tolerance; Immunosuppressive Agents - pharmacology; Immunosuppressive Agents - therapeutic use; INK4a protein; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; kidney transplant; Kidney Transplantation; Male; Middle Aged; Morphometry; Multicenter Studies as Topic - statistics & numerical data; Mycophenolic Acid - analogs & derivatives; Mycophenolic Acid - therapeutic use; Nephritis, Interstitial - chemically induced; Nephritis, Interstitial - immunology; Nephritis, Interstitial - metabolism; Nephritis, Interstitial - pathology; p16 protein; Randomized Controlled Trials as Topic - statistics & numerical data; Recombinant Fusion Proteins - therapeutic use; Senescence; senescense; Translational Studies; Human; senescense; Senescence; Calcineurin inhibitor; cyclosporin A; kidney transplant; expressing cells; Biochemistry; Belatacept; Transplantation; Kidney; Anatomic pathology; Regulation(control); Treatment; Urinary system; Biopsy; Surgery; Graft; Ciclosporin; Fusion protein; FoxP3; Cell; Transcription factor FOXP3; Comparative study

Summary Renal allograft survival is related directly to cell senescence. In the transplantation scenario many cellular events – participating as immunological and non‐immunological factors – could contribute to accelerate this biological process, responsible for the ultimate fate of the graft. Mecha...