The enzymes of glutathione synthesis: gamma-glutamylcysteine synthetase

• Published in: Advances in enzymology and related subjects Vol. 73; p. 209
• Main Authors: Griffith, O W, Mulcahy, R T
• Format: Journal Article
• Language: English
• Published: United States 01.01.1999
• Subjects: Animals; Cloning, Molecular; Drug Resistance, Neoplasm; Gene Expression Regulation; Glutamate-Cysteine Ligase - genetics; Glutamate-Cysteine Ligase - isolation & purification; Glutamate-Cysteine Ligase - metabolism; Glutathione - biosynthesis; Humans; Kinetics; Macromolecular Substances; Neoplasms - drug therapy; Neoplasms - enzymology; Recombinant Proteins - metabolism; Saccharomyces cerevisiae - enzymology; Substrate Specificity

The metabolite glutathione fulfills many important and chemically complex roles in protecting cellular components from the deleterious effects of toxic species. GSH combines with hydroxyl radical, peroxynitrite, and hydroperoxides, as well as reactive electrophiles, including activated phosphoramide...