WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13

• Published in: Molecular pharmacology Vol. 90; no. 4; pp. 447 - 459
• Main Authors: Arthofer, Elisa, Hot, Belma, Petersen, Julian, Strakova, Katerina, Jäger, Stefan, Grundmann, Manuel, Kostenis, Evi, Gutkind, J Silvio, Schulte, Gunnar
• Format: Journal Article
• Language: English
• Published: United States The American Society for Pharmacology and Experimental Therapeutics 01.10.2016
• Subjects: Dishevelled Proteins - metabolism; Fluorescence Recovery After Photobleaching; Fluorescence Resonance Energy Transfer; Frizzled Receptors - chemistry; Frizzled Receptors - metabolism; Green Fluorescent Proteins - metabolism; GTP-Binding Protein alpha Subunits, G12-G13 - metabolism; HEK293 Cells; Humans; Medicin och hälsovetenskap; Protein Binding - drug effects; Protein Domains; Rho Guanine Nucleotide Exchange Factors - metabolism; Signal Transduction - drug effects; Wnt Proteins - pharmacology

Frizzleds (FZDs) are unconventional G protein-coupled receptors that belong to the class Frizzled. They are bound and activated by the Wingless/Int-1 lipoglycoprotein (WNT) family of secreted lipoglycoproteins. To date, mechanisms of signal initiation and FZD-G protein coupling remain poorly underst...