Dose–response effects of TPI ASM8 in asthmatics after allergen

• Published in: Allergy (Copenhagen) Vol. 66; no. 9; pp. 1242 - 1248
• Main Authors: Gauvreau, G. M., Pageau, R., Séguin, R., Carballo, D., Gauthier, J., D’Anjou, H., Campbell, H., Watson, R., Mistry, M., Parry‐Billings, M., Killian, K., Renzi, P. M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2011; Blackwell
• Subjects: Adolescent; Adult; allergen challenge; Allergens; Allergens - administration & dosage; Allergens - immunology; Anti-Asthmatic Agents - administration & dosage; Anti-Asthmatic Agents - adverse effects; Anti-Asthmatic Agents - pharmacokinetics; Anti-Asthmatic Agents - therapeutic use; Antisense oligonucleotides; Asthma; Asthma - drug therapy; Asthma - genetics; Asthma - immunology; beta subunit of IL‐3, IL‐5, and GM‐CSF receptors; BID protein; Biological and medical sciences; CCR3 receptor; Chemokine receptors; Chronic obstructive pulmonary disease, asthma; Cytokine Receptor Common beta Subunit - genetics; Dermatology; Dose-response effects; Dose-Response Relationship, Drug; Drug dosages; Drug therapy; Eosinophil cationic protein; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene Expression Regulation - drug effects; Granulocyte-macrophage colony-stimulating factor; Humans; Inflammation; Interleukin 3; Interleukin 5; Leukocytes (eosinophilic); Male; Medical sciences; methacholine; Phosphorothioate Oligonucleotides - administration & dosage; Phosphorothioate Oligonucleotides - adverse effects; Phosphorothioate Oligonucleotides - pharmacokinetics; Phosphorothioate Oligonucleotides - therapeutic use; Pneumology; Receptors, CCR3 - genetics; Respiratory Hypersensitivity - drug therapy; Respiratory Hypersensitivity - immunology; Respiratory tract; RNA, Messenger - genetics; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Sputum; Sputum - immunology; Young Adult; Allergy; Subunit; Beta; Dose activity relation; Immunology; Interleukin 5; Interleukin 3; Dicotyledones; Angiospermae; Bronchus disease; Obstructive pulmonary disease; beta subunit of IL-3; Biological receptor; Lung disease; Immunopathology; Respiratory disease; Dermatology; Cytokine; IL-5; CCR3 chemokine receptor; Antisense oligonucleotide; allergen challenge; Chenopodiaceae; Asthma; and GM-CSF receptors; CCR3 receptor; antisense oligonucleotides; Spermatophyta; Granulocyte macrophage colony stimulating factor; Allergen; Provocation test

To cite this article: Gauvreau GM, Pageau R, Séguin R, Carballo D, Gauthier J, D’Anjou H, Campbell H, Watson R, Mistry M, Parry‐Billings M, Killian K, Renzi PM. Dose–response effects of TPI ASM8 in asthmatics after allergen. Allergy 2011; 66: 1242–1248. Background:  TPI ASM8 contains two modified an...