HIV‐1 Tat C modulates NOX2 and NOX4 expressions through miR‐17 in a human microglial cell line

• Published in: Journal of neurochemistry Vol. 131; no. 6; pp. 803 - 815
• Main Authors: Jadhav, Vaishnavi Sunil, Krause, Karl‐Heinz, Singh, Sunit K.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.12.2014
• Subjects: Cell Line; Cells, Cultured; Cellular biology; CNS; Cytokines; HIV; HIV-1 - isolation & purification; HIV-1 - metabolism; HIV‐1 Tat; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; Membrane Glycoproteins - metabolism; microglia; Microglia - metabolism; microRNA; MicroRNAs - metabolism; Mutagenesis, Site-Directed - methods; NADPH Oxidase 2; NADPH Oxidase 4; NADPH oxidases; NADPH Oxidases - metabolism; Neurological disorders; Proteins; Reactive Oxygen Species - metabolism; ROS; tat Gene Products, Human Immunodeficiency Virus - isolation & purification; tat Gene Products, Human Immunodeficiency Virus - metabolism; CNS; HIV-1 Tat; microRNA; NADPH oxidases; microglia; ROS

HIV‐1 invades CNS in the early course of infection, which can lead to the cascade of neuroinflammation. NADPH oxidases (NOXs) are the major producers of reactive oxygen species (ROS), which play important roles during pathogenic insults. The molecular mechanism of ROS generation via microRNA‐mediate...