CD38 deficiency suppresses adipogenesis and lipogenesis in adipose tissues through activating Sirt1/PPARγ signaling pathway

• Published in: Journal of cellular and molecular medicine Vol. 22; no. 1; pp. 101 - 110
• Main Authors: Wang, Ling‐Fang, Miao, Lian‐Jie, Wang, Xiao‐Nv, Huang, Cong‐Cong, Qian, Yi‐Song, Huang, Xuan, Wang, Xiao‐Lei, Jin, Wan‐Zhu, Ji, Guang‐Ju, Fu, Mingui, Deng, Ke‐Yu, Xin, Hong‐Bo
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.01.2018
• Subjects: adipogenesis; CD38; lipogenesis; Original; peroxisome proliferator‐activated receptor γ; Sirt1; CD38; Sirt1; lipogenesis; adipogenesis; peroxisome proliferator-activated receptor γ

It has been recently reported that CD38 was highly expressed in adipose tissues from obese people and CD38‐deficient mice were resistant to high‐fat diet (HFD)‐induced obesity. However, the role of CD38 in the regulation of adipogenesis and lipogenesis is unknown. In this study, to explore the roles...