No clinically significant association between CFH and ARMS2 genotypes and response to nutritional supplements: AREDS report number 38

• Published in: Ophthalmology (Rochester, Minn.) Vol. 121; no. 11; pp. 2173 - 2180
• Main Authors: Chew, Emily Y, Klein, Michael L, Clemons, Traci E, Agrón, Elvira, Ratnapriya, Rinki, Edwards, Albert O, Fritsche, Lars G, Swaroop, Anand, Abecasis, Gonçalo R
• Format: Journal Article
• Language: English
• Published: United States 01.11.2014
• Subjects: Aged; Antioxidants - administration & dosage; Complement Factor H - genetics; Dietary Supplements; Female; Genotype; Humans; Macular Degeneration - drug therapy; Macular Degeneration - genetics; Male; Polymorphism, Single Nucleotide; Prospective Studies; Proteins - genetics; Retrospective Studies; Vitamins - administration & dosage; Zinc Compounds - administration & dosage

To determine whether genotypes at 2 major loci associated with late age-related macular degeneration (AMD), complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2), influence the relative benefits of Age-Related Eye Disease Study (AREDS) supplements. Unplanned retrospective ev...