YAPping about and not forgetting TAZ

• Published in: FEBS letters Vol. 593; no. 3; pp. 253 - 276
• Main Authors: Callus, Bernard A., Finch‐Edmondson, Megan L., Fletcher, Sue, Wilton, Steve D.
• Format: Journal Article
• Language: English
• Published: England 01.02.2019
• Subjects: Animals; cancer; Cell Cycle Proteins; cellular localization; functional regulation; gene transcription; Hippo signalling; Humans; mechanotransduction; Mechanotransduction, Cellular; Neoplasm Proteins - metabolism; Neoplasms - metabolism; Neoplasms - pathology; Nuclear Proteins - metabolism; phosphodegron; Protein Stability; Protein-Serine-Threonine Kinases - metabolism; protein–protein interaction; Regeneration; stability; stem cells; Stem Cells - metabolism; Stem Cells - pathology; tissue repair; transcription (genetics); Transcription Factors - metabolism; transcriptional coactivator with PDZ‐binding motif; yes‐associated protein; gene transcription; cellular localization; functional regulation; transcriptional coactivator with PDZ-binding motif; yes-associated protein; cancer; protein-protein interaction; Hippo signalling; phosphodegron; stability

The Hippo pathway has emerged as a major eukaryotic signalling pathway and is increasingly the subject of intense interest, as are the key effectors of canonical Hippo signalling, YES‐associated protein (YAP) and TAZ. The Hippo pathway has key roles in diverse biological processes, including network...