Deadenylation by the CCR4‐NOT complex contributes to the turnover of hairy‐related mRNAs in the zebrafish segmentation clock

• Published in: FEBS letters Vol. 592; no. 20; pp. 3388 - 3398
• Main Authors: Fujino, Yuuri, Yamada, Kazuya, Sugaya, Chihiro, Ooka, Yuko, Ovara, Hiroki, Ban, Hiroyuki, Akama, Kagari, Otosaka, Shiori, Kinoshita, Hirofumi, Yamasu, Kyo, Mishima, Yuichiro, Kawamura, Akinori
• Format: Journal Article
• Language: English
• Published: England 01.10.2018
• Subjects: 3′UTR; Animals; Animals, Genetically Modified; Basic Helix-Loop-Helix Transcription Factors - genetics; Basic Helix-Loop-Helix Transcription Factors - metabolism; Biological Clocks; Body Patterning - genetics; Danio rerio; deadenylation; decapping; Exoribonucleases - genetics; Exoribonucleases - metabolism; Gene Expression Regulation, Developmental; genetically modified organisms; mesoderm; Mesoderm - embryology; Mesoderm - metabolism; mRNA decay; RNA Processing, Post-Transcriptional; RNA, Messenger - genetics; RNA, Messenger - metabolism; somite segmentation; Somites - embryology; Somites - metabolism; Transcription Factors - genetics; Transcription Factors - metabolism; zebrafish; Zebrafish - embryology; Zebrafish - genetics; Zebrafish - metabolism; Zebrafish Proteins - genetics; Zebrafish Proteins - metabolism; somite segmentation; zebrafish; decapping; deadenylation; 3′UTR; mRNA decay

In the zebrafish segmentation clock, hairy/enhancer of split‐related genes her1, her7, and hes6 encodes components of core oscillators. Since the expression of cyclic genes proceeds rapidly in the presomitic mesoderm (PSM), these hairy‐related mRNAs are subject to strict post‐transcriptional regulat...