Puerarin decreases hypoxia inducible factor-1 alpha in the hippocampus of vascular dementia rats
In this study, a rat vascular dementia model was established by permanent bilateral common carotid arterial occlusion. Rats were intraperitoneally injected with puerarin 3 days before modeling, for 45 successive days. Results demonstrated that in treated animals hippocampal structures were clear, ne...
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| Published in | Neural regeneration research Vol. 7; no. 6; pp. 421 - 425 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
India
Medknow Publications & Media Pvt. Ltd
25.02.2012
Department of Neurology, the Second Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China Medknow Publications & Media Pvt Ltd |
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| Online Access | Get full text |
| ISSN | 1673-5374 1876-7958 |
| DOI | 10.3969/j.issn.1673-5374.2012.06.003 |
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| Abstract | In this study, a rat vascular dementia model was established by permanent bilateral common carotid arterial occlusion. Rats were intraperitoneally injected with puerarin 3 days before modeling, for 45 successive days. Results demonstrated that in treated animals hippocampal structures were clear, nerve cells arranged neatly, and cytoplasm was rich in Nissl bodies. The number of cells positive for hypoxia inducible factor-1 alpha, erythropoietin and endothelial nitric oxide synthase was reduced; and the learning and memory abilities of rats were significantly improved. Our experimental findings indicate that puerarin can significantly improve learning and memory in a vascular dementia model, and that the underlying mechanism may be associated with the regulation of the expression of hypoxia inducible factor-1 alpha. |
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| AbstractList | In this study, a rat vascular dementia model was established by permanent bilateral common carotid arterial occlusion. Rats were intraperitoneally injected with puerarin 3 days before modeling, for 45 successive days. Results demonstrated that in treated animals hippocampal structures were clear, nerve cells arranged neatly, and cytoplasm was rich in Nissl bodies. The number of cells positive for hypoxia inducible factor-1 alpha, erythropoietin and endothelial nitric oxide synthase was reduced; and the learning and memory abilities of rats were significantly improved. Our experimental findings indicate that puerarin can significantly improve learning and memory in a vascular dementia model, and that the underlying mechanism may be associated with the regulation of the expression of hypoxia inducible factor-1 alpha. In this study, a rat vascular dementia model was established by permanent bilateral common carotid arterial occlusion. Rats were intraperitoneally injected with puerarin 3 days before modeling, for 45 successive days. Results demonstrated that in treated animals hippocampal structures were clear, nerve cells arranged neatly, and cytoplasm was rich in Nissl bodies. The number of cells positive for hypoxia inducible factor-1 alpha, erythropoietin and endothelial nitric oxide synthase was reduced; and the learning and memory abilities of rats were significantly improved. Our experimental findings indicate that puerarin can significantly improve learning and memory in a vascular dementia model, and that the underlying mechanism may be associated with the regulation of the expression of hypoxia inducible factor-1 alpha.In this study, a rat vascular dementia model was established by permanent bilateral common carotid arterial occlusion. Rats were intraperitoneally injected with puerarin 3 days before modeling, for 45 successive days. Results demonstrated that in treated animals hippocampal structures were clear, nerve cells arranged neatly, and cytoplasm was rich in Nissl bodies. The number of cells positive for hypoxia inducible factor-1 alpha, erythropoietin and endothelial nitric oxide synthase was reduced; and the learning and memory abilities of rats were significantly improved. Our experimental findings indicate that puerarin can significantly improve learning and memory in a vascular dementia model, and that the underlying mechanism may be associated with the regulation of the expression of hypoxia inducible factor-1 alpha. Q189; In this study, a rat vascular dementia model was established by permanent bilateral common carotid arterial occlusion. Rats were intraperitoneally injected with puerarin 3 days before modeling, for 45 successive days. Results demonstrated that in treated animals hippocampal structures were clear, nerve cells arranged neatly, and cytoplasm was rich in Nissl bodies. The number of cells positive for hypoxia inducible factor-1 alpha, erythropoietin and endothelial nitric oxide synthase was reduced; and the learning and memory abilities of rats were significantly improved. Our experimental findings indicate that puerarin can significantly improve learning and memory in a vascular dementia model, and that the underlying mechanism may be associated with the regulation of the expression of hypoxia inducible factor-1 alpha. |
| Author | Zhang, Ru Zhang, Bei Wu, Haiqin Zhang, Guilian Wang, Huqing Zhang, Lingfeng |
| AuthorAffiliation | Department of Neurology, the Second Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China |
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| Keywords | puerarin endothelial nitric-oxide synthase vascular dementia hypoxia-inducible factor-1 alpha erythropoietin |
| Language | English |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Haiqin Wu, M.D., Professor, Department of Neurology, the Second Affiliated Hospital, Medical College of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China Author contributions: Haiqin Wu designed this study and revised the manuscript. Huqing Wang and Bei Zhang provided experimental data, participated in statistical analysis and wrote the manuscript. Guilian Zhang and Ru Zhang provided technical support and statistical calculations. Lingfeng Zhang provided information support. |
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| SubjectTerms | Animals Ataxia Carotid arteries Cytoplasm Dementia Drug dosages Dyskinesia Hypoxia Ischemia Medical research Memory Research and Report: Traditional Chinese Medicine and Neuroregeneration |
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| Title | Puerarin decreases hypoxia inducible factor-1 alpha in the hippocampus of vascular dementia rats |
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