Leveraging Foundational Models in Computational Biology: Validation, Understanding, and Innovation

• Published in: Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing Vol. 30; p. 702
• Main Authors: Beaulieu-Jones, Brett, Brenner, Steven
• Format: Journal Article
• Language: English
• Published: United States 2025
• Subjects: Computational Biology; Humans; Natural Language Processing; Validation Studies as Topic

Large Language Models (LLMs) have shown significant promise across a wide array of fields, including biomedical research, but face notable limitations in their current applications. While they offer a new paradigm for data analysis and hypothesis generation, their efficacy in computational biology t...