Aging is associated with altered inflammatory, arachidonic acid cascade, and synaptic markers, influenced by epigenetic modifications, in the human frontal cortex

• Published in: Journal of neurochemistry Vol. 125; no. 1; pp. 63 - 73
• Main Authors: Keleshian, Vasken L, Modi, Hiren R, Rapoport, Stanley I, Rao, Jagadeesh S
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.04.2013
• Subjects: Adult; Aged; Aged, 80 and over; Aging; Aging - immunology; Aging - metabolism; Alzheimer's disease; Apoptosis; Arachidonic Acid - metabolism; Biomarkers - metabolism; DNA Methylation; Epigenesis, Genetic; Epigenetics; Frontal Lobe - metabolism; Gene expression; Humans; Inflammation - metabolism; Middle Aged; Neurochemistry; Synapses - metabolism

Aging is a risk factor for Alzheimer's disease (AD) and is associated with cognitive decline. However, underlying molecular mechanisms of brain aging are not clear. Recent studies suggest epigenetic influences on gene expression in AD, as DNA methylation levels influence protein and mRNA expres...