Exosome-Mediated miR-155 Transfer from Smooth Muscle Cells to Endothelial Cells Induces Endothelial Injury and Promotes Atherosclerosis

• Published in: Molecular therapy Vol. 25; no. 6; pp. 1279 - 1294
• Main Authors: Zheng, Bin, Yin, Wei-Na, Suzuki, Toru, Zhang, Xin-Hua, Zhang, Yu, Song, Li-Li, Jin, Li-Shuang, Zhan, Hong, Zhang, Hong, Li, Jin-Shui, Wen, Jin-Kun
• Format: Journal Article
• Language: English
• Published: United States Elsevier Limited 07.06.2017; American Society of Gene & Cell Therapy
• Subjects: Animals; Arteriosclerosis; Atherosclerosis; Atherosclerosis - genetics; Atherosclerosis - metabolism; Atherosclerosis - pathology; Biological Transport; Cell Membrane Permeability; Cell proliferation; Communication; Disease Models, Animal; Endothelial cells; Endothelial Cells - metabolism; Endothelium; Endothelium - metabolism; Endothelium - pathology; Exosomes; Exosomes - metabolism; Gene Deletion; Gene Transfer Techniques; Human Umbilical Vein Endothelial Cells - metabolism; Humans; Leukocyte migration; Macrophages; Male; Mice; Mice, Knockout; Mice, Transgenic; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Models, Biological; Mutation; Myocytes, Smooth Muscle - metabolism; Original; Permeability; Physiology; Regulation; Smooth muscle; Therapeutic applications; Tight junctions; Veins & arteries; China; miR-155; KLF5; endothelial barriers

The vascular response to pro-atherosclerotic factors is a multifactorial process involving endothelial cells (ECs), macrophages (MACs), and smooth muscle cells (SMCs), although the mechanism by which these cell types communicate with each other in response to environmental cues is yet to be understo...