Fatigue in levodopa-naive subjects with Parkinson disease

• Published in: Neurology Vol. 71; no. 7; p. 481
• Main Authors: Schifitto, G, Friedman, J H, Oakes, D, Shulman, L, Comella, C L, Marek, K, Fahn, S
• Format: Journal Article
• Language: English
• Published: United States 12.08.2008
• Subjects: Aged; Antiparkinson Agents - therapeutic use; Brain - metabolism; Carbidopa - therapeutic use; Double-Blind Method; Fatigue - etiology; Female; Humans; Levodopa - therapeutic use; Male; Middle Aged; Parkinson Disease - complications; Parkinson Disease - drug therapy; Parkinson Disease - physiopathology; Tomography, Emission-Computed, Single-Photon

Fatigue is a common complaint in Parkinson disease (PD). We investigated fatigue in a cohort of previously untreated patients with early PD enrolled in the Earlier vs Later Levodopa (ELLDOPA) clinical trial. A total of 361 patients were enrolled in the randomized, double-blind, placebo-controlled EL...