Mortality Benefit With Prasugrel in the TRITON―TIMI 38 Coronary Artery Bypass Grafting Cohort: Risk-Adjusted Retrospective Data Analysis

• Published in: Journal of the American College of Cardiology Vol. 60; no. 5; pp. 388 - 396
• Main Authors: SMITH, Peter K, GOODNOUGH, Lawrence T, LEVY, Jerrold H, POSTON, Robert S, SHORT, Mary A, WEERAKKODY, Govinda J, LENARZ, Leroy A
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier 31.07.2012; Elsevier Limited
• Subjects: Acute Coronary Syndrome - mortality; Acute Coronary Syndrome - surgery; Aged; Angioplasty, Balloon, Coronary - mortality; Aspirin - adverse effects; Aspirin - therapeutic use; Biological and medical sciences; Blood Loss, Surgical; Cardiology; Cardiology. Vascular system; Cause of Death; Chest Tubes; Cohort Studies; Combined Modality Therapy; Coronary Artery Bypass - mortality; Coronary heart disease; Coronary vessels; Drug Administration Schedule; Drug therapy; Drug Therapy, Combination; Erythrocyte Transfusion; Female; Follow-Up Studies; Heart; Heart attacks; Hemorrhage - chemically induced; Humans; Male; Medical sciences; Middle Aged; Mortality; Piperazines - administration & dosage; Piperazines - adverse effects; Platelet Aggregation Inhibitors - administration & dosage; Platelet Aggregation Inhibitors - adverse effects; Prasugrel Hydrochloride; Recurrence; Retrospective Studies; Risk Adjustment; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the heart; Thiophenes - administration & dosage; Thiophenes - adverse effects; Ticlopidine - administration & dosage; Ticlopidine - adverse effects; Ticlopidine - analogs & derivatives; Prasugrel; Data analysis; Prognosis; Coronary artery bypass; Mortality; Cardiovascular disease; Circulatory system; Risk analysis; Cardiology; Coronary heart disease; Retrospective

The objective of this study was to characterize the bleeding, transfusion, and other outcomes of patients related to the timing of prasugrel or clopidogrel withdrawal before coronary artery bypass grafting (CABG). There is little evidence to guide clinical decision making regarding the use of prasug...