Deficient immune interferon production in tuberculosis
Production of interferon (IFN)-alpha and -gamma by peripheral blood mononuclear cells (PBMC) were studied in 28 patients with active tuberculosis and 28 healthy control subjects matched for age, sex, ethnic origin and diet. No significant differences were found between patients and matched controls...
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| Published in | Clinical and experimental immunology Vol. 59; no. 2; pp. 405 - 413 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Blackwell
01.02.1985
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0009-9104 1365-2249 |
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| Abstract | Production of interferon (IFN)-alpha and -gamma by peripheral blood mononuclear cells (PBMC) were studied in 28 patients with active tuberculosis and 28 healthy control subjects matched for age, sex, ethnic origin and diet. No significant differences were found between patients and matched controls in mean titres of IFN-alpha induced by Newcastle disease virus, IFN-gamma induced by staphylococcal enterotoxin A with tetrahydrophorbyl acetate, and IFN-gamma induced by purified protein derivative (PPD). However, a subset of nine out of 25 tuberculosis patients tested produced low titres (less than 100 u/ml) of IFN-gamma in response to PBMC stimulation with PPD. In comparison to other patients, this group was characterized by lower IFN-alpha and IFN-gamma responses to virus and mitogens respectively, relative anergy to tuberculin skin testing, depressed in vitro PBMC proliferative responses to PPD, and neutrophil leucocytosis. In all nine patients effective chemotherapy restored cutaneous reactivity, PBMC proliferative responses, neutrophil counts and IFN-alpha responses to virus by 6 months, and also IFN-gamma responses to PPD in one patient re-tested. |
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| AbstractList | Production of interferon (IFN)-alpha and -gamma by peripheral blood mononuclear cells (PBMC) were studied in 28 patients with active tuberculosis and 28 healthy control subjects matched for age, sex, ethnic origin and diet. No significant differences were found between patients and matched controls in mean titres of IFN-alpha induced by Newcastle disease virus, IFN-gamma induced by staphylococcal enterotoxin A with tetrahydrophorbyl acetate, and IFN-gamma induced by purified protein derivative (PPD). However, a subset of nine out of 25 tuberculosis patients tested produced low titres (less than 100 u/ml) of IFN-gamma in response to PBMC stimulation with PPD. In comparison to other patients, this group was characterized by lower IFN-alpha and IFN-gamma responses to virus and mitogens respectively, relative anergy to tuberculin skin testing, depressed in vitro PBMC proliferative responses to PPD, and neutrophil leucocytosis. In all nine patients effective chemotherapy restored cutaneous reactivity, PBMC proliferative responses, neutrophil counts and IFN-alpha responses to virus by 6 months, and also IFN-gamma responses to PPD in one patient re-tested. Production of interferon (IFN)- alpha and gamma - by peripheral blood mononuclear cells (PBMC) were studied in 28 patients with active tuberculosis and 28 healthy control subjects matched for age, sex, ethnic origin and diet. No significant differences were found between patients and matched controls in mean titres of IFN- alpha induced by Newcastle disease virus, IFN- gamma induced by staphylococcal enterotoxin A with tetrahydrophorbyl acetate, and IFN- gamma induced by purified protein derivative (PPD). However, a subset of nine out of 25 tuberculosis patients tested produced low titres (< 100 u/ml) of IFN- gamma in response to PBMC stimulation with PPD. In comparison to other patients, this group was characterized by lower IFN- alpha and IFN- gamma responses to virus and mitogens respectively, relative anergy to tuberculin skin testing, depressed in vitro PBMC proliferative responses to PPD, and neutrophil leucocytosis. Production of interferon (IFN)-alpha and -gamma by peripheral blood mononuclear cells (PBMC) were studied in 28 patients with active tuberculosis and 28 healthy control subjects matched for age, sex, ethnic origin and diet. No significant differences were found between patients and matched controls in mean titres of IFN-alpha induced by Newcastle disease virus, IFN-gamma induced by staphylococcal enterotoxin A with tetrahydrophorbyl acetate, and IFN-gamma induced by purified protein derivative (PPD). However, a subset of nine out of 25 tuberculosis patients tested produced low titres (less than 100 u/ml) of IFN-gamma in response to PBMC stimulation with PPD. In comparison to other patients, this group was characterized by lower IFN-alpha and IFN-gamma responses to virus and mitogens respectively, relative anergy to tuberculin skin testing, depressed in vitro PBMC proliferative responses to PPD, and neutrophil leucocytosis. In all nine patients effective chemotherapy restored cutaneous reactivity, PBMC proliferative responses, neutrophil counts and IFN-alpha responses to virus by 6 months, and also IFN-gamma responses to PPD in one patient re-tested.Production of interferon (IFN)-alpha and -gamma by peripheral blood mononuclear cells (PBMC) were studied in 28 patients with active tuberculosis and 28 healthy control subjects matched for age, sex, ethnic origin and diet. No significant differences were found between patients and matched controls in mean titres of IFN-alpha induced by Newcastle disease virus, IFN-gamma induced by staphylococcal enterotoxin A with tetrahydrophorbyl acetate, and IFN-gamma induced by purified protein derivative (PPD). However, a subset of nine out of 25 tuberculosis patients tested produced low titres (less than 100 u/ml) of IFN-gamma in response to PBMC stimulation with PPD. In comparison to other patients, this group was characterized by lower IFN-alpha and IFN-gamma responses to virus and mitogens respectively, relative anergy to tuberculin skin testing, depressed in vitro PBMC proliferative responses to PPD, and neutrophil leucocytosis. In all nine patients effective chemotherapy restored cutaneous reactivity, PBMC proliferative responses, neutrophil counts and IFN-alpha responses to virus by 6 months, and also IFN-gamma responses to PPD in one patient re-tested. |
| Author | ONWUBALILI, J. K ROBINSON, J. A SCOTT, G. M |
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| Keywords | Human Cell culture Induction Evolutivity Functional deficit Delayed hypersensitivity Cellular immunity Lymphokine Mycobacterial infection Blood Infection Tuberculin PPD Mononuclear cell Tuberculosis Production Bacteriosis Gamma interferon |
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| References_xml | – reference: 6411853 - J Exp Med. 1983 Sep 1;158(3):670-89 – reference: 517859 - Am Rev Respir Dis. 1979 Dec;120(6):1275-8 – reference: 7266662 - Nature. 1981 Sep 3;293(5827):69-71 – reference: 5783715 - Science. 1969 Jun 20;164(3886):1415-7 – reference: 6170851 - Lancet. 1981 Oct 31;2(8253):950-2 – reference: 849655 - Clin Exp Immunol. 1977 Feb;27(2):230-7 – reference: 6814775 - Bull World Health Organ. 1982;60(4):447-62 – reference: 309907 - J Immunol. 1978 Dec;121(6):2573-9 – reference: 6972952 - J Clin Invest. 1981 Jul;68(1):153-62 – reference: 16695958 - J Clin Invest. 1971 Apr;50(4):744-53 – reference: 226483 - Int J Cancer. 1979 Aug;24(2):178-83 – reference: 786253 - Bacteriol Rev. 1976 Jun;40(2):284-313 – reference: 381523 - J Immunol Methods. 1979;27(3):219-23 – reference: 15776572 - J Exp Med. 1971 Sep 1;134(3 Pt 1):741-50 – reference: 6173323 - Infect Immun. 1982 Feb;35(2):383-90 – reference: 5913732 - Int Arch Allergy Appl Immunol. 1966;30(1):58-66 – reference: 730351 - Infect Immun. 1978 Oct;22(1):62-8 – reference: 6976936 - Infect Immun. 1982 Feb;35(2):402-9 – reference: 7015488 - Scand J Immunol. 1981;13(3):289-96 – reference: 6170583 - Infect Immun. 1981 Oct;34(1):131-9 – reference: 16558073 - Infect Immun. 1973 Jan;7(1):68-75 – reference: 5943935 - J Bacteriol. 1966 Jun;91(6):2185-91 – reference: 6415111 - J Clin Invest. 1983 Oct;72(4):1506-10 – reference: 826362 - Clin Exp Immunol. 1976 Oct;26(1):129-32 – reference: 414398 - Tubercle. 1977 Dec;58(4):207-15 – reference: 6774019 - J Immunol. 1980 Sep;125(3):1380-6 – reference: 108041 - Clin Exp Immunol. 1979 Feb;35(2):250-7 – reference: 300226 - Am Rev Respir Dis. 1977 Feb;115(2):207-12 – reference: 4360795 - Cell Immunol. 1971 Dec;2(6):602-13 – reference: 110887 - J Infect Dis. 1979 Jul;140(1):12-21 – reference: 6163989 - Nature. 1981 Apr 9;290(5806):501-3 – reference: 6415179 - J Infect Dis. 1983 Oct;148(4):676-81 – reference: 6968170 - Am Rev Respir Dis. 1980 Jun;121(6):951-7 – reference: 6313807 - J Immunol. 1983 Nov;131(5):2542-4 – reference: 5411978 - Int Arch Allergy Appl Immunol. 1970;38(2):119-29 |
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| Snippet | Production of interferon (IFN)-alpha and -gamma by peripheral blood mononuclear cells (PBMC) were studied in 28 patients with active tuberculosis and 28... Production of interferon (IFN)- alpha and gamma - by peripheral blood mononuclear cells (PBMC) were studied in 28 patients with active tuberculosis and 28... |
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| SubjectTerms | Adolescent Adult Bacterial diseases Biological and medical sciences Cells, Cultured Female Human bacterial diseases Humans Infectious diseases Interferon Inducers Interferon Type I - biosynthesis Interferon-gamma - biosynthesis Interferons - biosynthesis Leukocytes - immunology Male Medical sciences Middle Aged Mitosis Tuberculin - pharmacology Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - immunology |
| Title | Deficient immune interferon production in tuberculosis |
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