Human Fis1 regulates mitochondrial dynamics through inhibition of the fusion machinery

• Published in: The EMBO journal Vol. 38; no. 8
• Main Authors: Yu, Rong, Jin, Shao‐Bo, Lendahl, Urban, Nistér, Monica, Zhao, Jian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.04.2019; Springer Nature B.V; John Wiley and Sons Inc
• Subjects: Divergence; Drp1; Dynamics; Dynamin; Dynamins - genetics; Dynamins - metabolism; EMBO20; Fission; Fragmentation; GTP Phosphohydrolases - genetics; GTP Phosphohydrolases - metabolism; Guanosine triphosphatases; HeLa Cells; hFis1; Homology; Humans; Mammals; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mitochondria; Mitochondrial Dynamics; Mitochondrial Membrane Transport Proteins - genetics; Mitochondrial Membrane Transport Proteins - metabolism; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; mitofusins; OPA1; Phenotypes; Proteins; Yeast; hFis1; OPA1; mitofusins; Drp1; mitochondrial dynamics

Mitochondrial dynamics is important for life. At center stage for mitochondrial dynamics, the balance between mitochondrial fission and fusion is a set of dynamin‐related GTPases that drive mitochondrial fission and fusion. Fission is executed by the GTPases Drp1 and Dyn2, whereas the GTPases Mfn1,...