Collagenase-3 (MMP-13) is expressed during human fetal ossification and re-expressed in postnatal bone remodeling and in rheumatoid arthritis

• Published in: Laboratory investigation Vol. 76; no. 5; pp. 717 - 728
• Main Authors: STAHLE-BÄCKDAHL, M, SANDSTEDT, B, BRUCE, K, LINDAHL, A, JIMENEZ, M. G, VEGA, J. A, LOPEZ-OTIN, C
• Format: Journal Article
• Language: English
• Published: New York, NY Nature Publishing 01.05.1997
• Subjects: Aged; Arthritis, Rheumatoid - enzymology; Arthritis, Rheumatoid - metabolism; Biological and medical sciences; Bone Remodeling - genetics; Child; Child, Preschool; Collagenases - biosynthesis; Collagenases - genetics; Diseases of the osteoarticular system; Embryonic and Fetal Development - genetics; Female; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; Gelatinases - biosynthesis; Humans; Infant; Inflammatory joint diseases; Matrix Metalloproteinase 13; Matrix Metalloproteinase 2; Medical sciences; Medicin och hälsovetenskap; Metalloendopeptidases - biosynthesis; Middle Aged; Osteogenesis - genetics; RNA, Messenger - analysis; Skeleton and joints; Synovial Fluid - chemistry; Vertebrates: osteoarticular system, musculoskeletal system; Human; Immunopathology; Enzyme; Diseases of the osteoarticular system; Autoimmune disease; Inflammatory joint disease; Ossification; Peptidases; Chronic; Rheumatoid arthritis; Development; Hydrolases; Fetus

To explore possible physiologic functions for the metalloproteinase collagenase-3, we have examined its temporal and spatial expression during human fetal development. Except for mesenchymal cells in the umbilical cord at 4 weeks of gestation, signal for collagenase-3 mRNA was confined to mineralizi...