Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts - Kim, Tae Hyung; Kim, Hyuk Soon; Kang, Yoon Jong; Yoon, Sungpil; Lee, Jaewon; Choi, Wahn Soo; Jung, Jee H; Kim, Hyung Sik (Biochimica et biophysica acta, 2015)
Keywords: acetylation; Acetylation - drug effects; Animals; Antibiotics, Antineoplastic - pharmacology; antineoplastic activity; apoptosis; autophagy; Autophagy - drug effects; Autophagy - genetics; breast neoplasms; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; cell cycle checkpoints; Cell Division - drug effects; Cell Division - genetics; Cell Line, Tumor; cell proliferation; cultured cells; Disulfides - pharmacology; Doxorubicin - pharmacology; Drug Resistance, Neoplasm - drug effects; Drug Resistance, Neoplasm - genetics; enzyme activity; Female; G2 Phase - drug effects; G2 Phase - genetics; Gene Expression Regulation, Neoplastic - drug effects; Gene Expression Regulation, Neoplastic - genetics; Heterografts; Humans; Membrane Proteins - biosynthesis; Membrane Proteins - genetics; Mice; Mice, Nude; multiple drug resistance; neoplasm cells; Neoplasm Transplantation; new drugs; Porifera; proteins; Sirtuin 1 - biosynthesis; Sirtuin 1 - genetics; toxicity; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Tyrosine - analogs & derivatives; Tyrosine - pharmacology; Xenograft Model Antitumor Assays - methods; Breast cancer; Drug-resistant; Autophagy; Doxorubicin; SIRT1