ESX‐1‐induced apoptosis is involved in cell‐to‐cell spread of Mycobacterium tuberculosis

• Published in: Cellular microbiology Vol. 15; no. 12; pp. 1994 - 2005
• Main Authors: Aguilo, J. I., Alonso, H., Uranga, S., Marinova, D., Arbués, A., Martino, A., Anel, A., Monzon, M., Badiola, J., Pardo, J., Brosch, Roland, Martin, Carlos
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.12.2013
• Subjects: Animals; Antigens, Bacterial - genetics; Antigens, Bacterial - metabolism; Apoptosis; Apoptosis - immunology; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacterial Proteins - secretion; BCG Vaccine - immunology; Female; Green Fluorescent Proteins; Homeodomain Proteins - metabolism; Humans; Infections; Macrophages - microbiology; Mice; Mice, Inbred C57BL; Mycobacterium tuberculosis; Mycobacterium tuberculosis - metabolism; Mycobacterium tuberculosis - pathogenicity; Tuberculosis; Tuberculosis - transmission

Summary Apoptosis modulation is a procedure amply utilized by intracellular pathogens to favour the outcome of the infection. Nevertheless, the role of apoptosis during infection with Mycobacterium tuberculosis, the causative agent of human tuberculosis, is subject of an intense debate and still rem...