SATB1 promotes tumor metastasis and invasiveness in oral squamous cell carcinoma

• Published in: Oral diseases Vol. 23; no. 2; pp. 247 - 254
• Main Authors: Li, Y‐C, Bu, L‐L, Mao, L., Ma, S‐R, Liu, J‐F, Yu, G‐T, Deng, W‐W, Zhang, W‐F, Sun, Z‐J
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.03.2017
• Subjects: Carcinoma, Squamous Cell - chemistry; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - secondary; Cell Line, Tumor; Cell Movement - genetics; epithelial to mesenchymal transition; Epithelial-Mesenchymal Transition - drug effects; Epithelial-Mesenchymal Transition - genetics; Gene Knockdown Techniques; Humans; Lymphatic Metastasis; Matrix Attachment Region Binding Proteins - analysis; Matrix Attachment Region Binding Proteins - genetics; Metastasis; Mouth Neoplasms - chemistry; Mouth Neoplasms - genetics; Mouth Neoplasms - pathology; Neoplasm Invasiveness - genetics; Neoplasm Staging; Oral cancer; oral squamous cell carcinoma; SATB1; Transforming Growth Factor beta - pharmacology; Tumors; epithelial to mesenchymal transition; oral squamous cell carcinoma; SATB1; metastasis

Objective Our aim is to evaluate the expression of SATB1 in human oral squamous cell carcinomas (OSCC) and its role in the invasiveness and metastasis of OSCC. Subjects and methods A human OSCC tissue microarray was used to evaluate the expression pattern of SATB1. SATB1 mRNA knockdown was performed...