In vivo and in vitro degradation of peptide YY3-36 to inactive peptide YY3-34 in humans

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology Vol. 310; no. 9; pp. R866 - R874
• Main Authors: Toräng, Signe, Bojsen-Møller, Kirstine Nyvold, Svane, Maria Saur, Hartmann, Bolette, Rosenkilde, Mette Marie, Madsbad, Sten, Holst, Jens Juul
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.05.2016
• Subjects: Animals; Blood Glucose; Blood Pressure; Cercopithecus aethiops; COS Cells; Hormones, Reproduction and Development; Humans; Male; Obesity, Diabetes and Energy Homeostasis; Peptide Fragments - chemistry; Peptide Fragments - metabolism; Peptide YY - chemistry; Peptide YY - metabolism; Proteolysis; Single-Blind Method; Young Adult; kinetics; degradation; peptide YY

Peptide YY (PYY) is a 36-amino-acid peptide released from enteroendocrine cells upon food intake. The NH2 terminally truncated metabolite, PYY3-36, exerts anorexic effects and has received considerable attention as a possible antiobesity drug target. The kinetics and degradation products of PYY meta...