Spinal 5-HT3 receptor contributes to somatic hyperalgesia induced by sub-chronic stress

• Published in: Molecular pain Vol. 15; p. 1744806919859723
• Main Authors: Li, Zhuo-Lin, Xue, Yang, Tao, Zhuo-Ying, Du, Wen-Zhi, Jiang, Yue-Gui, Cao, Dong-Yuan
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.07.2019; Sage Publications Ltd
• Subjects: 17β-Estradiol; Filaments; Hyperalgesia; Latency; Ovariectomy; Pain; Pain perception; Receptor mechanisms; Serotonin S3 receptors; Spinal cord; stress-induced hyperalgesia; descending facilitation; Pain; spinal cord; forced swim; 5-HT3 receptor

Stress facilitates pain perception and sensitizes pain pathways, but the underlying mechanism is still unclear. The purpose of this study was to investigate whether the activation of 5-hydroxytryptamine (5-HT) subtype-3 receptor in the spinal cord contributes to somatic hyperalgesia induced by repea...