Fungal aryl-alcohol oxidase: a peroxide-producing flavoenzyme involved in lignin degradation

• Published in: Applied microbiology and biotechnology Vol. 93; no. 4; pp. 1395 - 1410
• Main Authors: Hernández-Ortega, Aitor, Ferreira, Patricia, Martínez, Angel T.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.02.2012; Springer Nature B.V
• Subjects: active sites; Alcohol; Alcohol Oxidoreductases; Alcohol Oxidoreductases - chemistry; Alcohol Oxidoreductases - genetics; Alcohol Oxidoreductases - metabolism; Alcohols; Aldehydes; Alternative energy sources; Analysis; Basidiomycetes; Biodegradation; Biomass; Biomedical and Life Sciences; Biorefineries; Biotechnology; Biotransformation; Carbon; Catalysis; catalytic activity; Cellulose; Chemicals; chemistry; Degradation; Ecosystems; Emission standards; enantiomers; Enzymes; enzymology; Flavoproteins; Flavoproteins - chemistry; Flavoproteins - genetics; Flavoproteins - metabolism; flavor; Fungi; Fungi - enzymology; genetics; Genomes; Hydrides; Hydrogen peroxide; isotopes; Life Sciences; Lignin; Lignin - metabolism; Lignocellulose; metabolism; Metabolites; Microbial Genetics and Genomics; Microbiology; Microorganisms; Mini-Review; Models, Biological; Models, Chemical; Models, Molecular; Oxidase; oxidation; peroxidases; Peroxides; Peroxides - metabolism; Phylogeny; Pleurotus; Pleurotus eryngii; Protein Conformation; protons; Recycling; Sequence Homology, Amino Acid; site-directed mutagenesis; Stereoselectivity; Studies; Stereoselectivity; Reaction mechanism; Lignin biodegradation; Fungal enzymes; GMC oxidoreductases; Aryl-alcohol oxidase

Aryl-alcohol oxidase (AAO) is an extracellular flavoprotein providing the H 2 O 2 required by ligninolytic peroxidases for fungal degradation of lignin, the key step for carbon recycling in land ecosystems. O 2 activation by Pleurotus eryngii AAO takes place during the redox-cycling of p- methoxylat...