Lipoprotein(a) Is Markedly More Atherogenic Than LDL: An Apolipoprotein B-Based Genetic Analysis

• Published in: Journal of the American College of Cardiology Vol. 83; no. 3; pp. 385 - 395
• Main Authors: Björnson, Elias, Adiels, Martin, Taskinen, Marja-Riitta, Burgess, Stephen, Chapman, M John, Packard, Chris J, Borén, Jan
• Format: Journal Article
• Language: English
• Published: United States 23.01.2024
• Subjects: Apolipoproteins B - genetics; Cardiology and Cardiovascular Disease; cardiovascular disease; Cholesterol, LDL; Coronary Disease - epidemiology; Coronary Disease - genetics; Genome-Wide Association Study; Humans; Kardiologi och kardiovaskulära sjukdomar; LDL cholesterol; lipoprotein(a); Lipoprotein(a) - genetics; Mendelian randomization; Risk Factors; UK Biobank; cardiovascular disease; Mendelian randomization; LDL cholesterol; UK Biobank; lipoprotein(a)

Lipoprotein(a) (Lp(a)) is recognized as a causal factor for coronary heart disease (CHD) but its atherogenicity relative to that of low-density lipoprotein (LDL) on a per-particle basis is indeterminate. The authors addressed this issue in a genetic analysis based on the fact that Lp(a) and LDL both...