Multi-stimuli responsive Cu2S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agents

• Published in: Nanoscale Vol. 7; no. 18; pp. 8378 - 8388
• Main Authors: Poulose, Aby Cheruvathoor, Veeranarayanan, Srivani, Mohamed, M Sheikh, Nagaoka, Yutaka, Aburto, Rebeca Romero, Mitcham, Trevor, Ajayan, Pulickel M, Bouchard, Richard R, Sakamoto, Yasushi, Yoshida, Yasuhiko, Maekawa, Toru, Kumar, D Sakthi
• Format: Journal Article
• Language: English
• Published: England 14.05.2015
• Subjects: Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemistry; Contrast Media - chemical synthesis; Copper - chemistry; Copper - radiation effects; Delayed-Action Preparations - chemical synthesis; Doxorubicin - administration & dosage; Doxorubicin - chemistry; Elasticity Imaging Techniques - methods; Hydrogen-Ion Concentration; Light; Metal Nanoparticles - chemistry; Metal Nanoparticles - radiation effects; Metal Nanoparticles - ultrastructure; Microscopy, Fluorescence - methods; Multimodal Imaging - methods; Nanocapsules - chemistry; Nanocapsules - radiation effects; Nanocapsules - ultrastructure; Photochemotherapy - methods; Theranostic Nanomedicine - methods; Tomography, X-Ray Computed - methods

A size and shape tuned, multifunctional metal chalcogenide, Cu2S-based nanotheranostic agent is developed for trimodal imaging and multimodal therapeutics against brain cancer cells. This theranostic agent was highly efficient in optical, photoacoustic and X-ray contrast imaging systems. The folate...