Rationale and design of the CAREFUL study The yield of CARdiogenetic scrEening in First degree relatives of sudden cardiac and UnexpLained death victims <45 years
Background. Sudden cardiac death (SCD) in the young (1-45 years) is a strong risk factor for the presence of inherited cardiac diseases in surviving first-degree relatives. Postmortem investigation of the victim and cardiogenetic evaluation of the first-degree relatives is indicated to detect inheri...
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Published in | Netherlands heart journal Vol. 18; no. 6; pp. 286 - 290 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | Dutch English |
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Houten
Bohn Stafleu van Loghum
01.06.2010
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Abstract | Background. Sudden cardiac death (SCD) in the young (1-45 years) is a strong risk factor for the presence of inherited cardiac diseases in surviving first-degree relatives. Postmortem investigation of the victim and cardiogenetic evaluation of the first-degree relatives is indicated to detect inherited cardiac diseases and treat relatives at an early stage to prevent SCD. In the Netherlands, postmortem investigation is often not performed and relatives of SCD and sudden unexplained death (SUD) victims are rarely evaluated for inherited cardiac diseases.Methods. A prospective population-based follow-up study carried out in two intervention regions and two control regions. In the intervention regions a comprehensive intervention (stimulate autopsy and storage of victims DNA and the referral of first-degree relatives for cardiogenetic evaluation) is applied in a 'top down' and 'bottom up' mode. In each region, young sudden death victims are registered and for all cases performance of autopsy and evaluation of relatives in a cardiogenetics outpatient clinic will be determined.Expected results. The study will provide information on the incidence of sudden death in the young and the proportion of diagnosed inherited cardiac diseases. Moreover, the additional value of the introduction of two different preventive strategies directed at early detection of inherited cardiac diseases in first-degree relatives to usual care will be evaluated. Conclusion. The CAREFUL study will help to set a new standard of care in the evaluation of young sudden death victims and their relatives to identify the presence of inherited cardiac diseases, in order to prevent sudden death. (Neth Heart J 2010;18:286-90.). |
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AbstractList | Background. Sudden cardiac death (SCD) in the young (1-45 years) is a strong risk factor for the presence of inherited cardiac diseases in surviving first-degree relatives. Postmortem investigation of the victim and cardiogenetic evaluation of the first-degree relatives is indicated to detect inherited cardiac diseases and treat relatives at an early stage to prevent SCD. In the Netherlands, postmortem investigation is often not performed and relatives of SCD and sudden unexplained death (SUD) victims are rarely evaluated for inherited cardiac diseases.Methods. A prospective population-based follow-up study carried out in two intervention regions and two control regions. In the intervention regions a comprehensive intervention (stimulate autopsy and storage of victims DNA and the referral of first-degree relatives for cardiogenetic evaluation) is applied in a 'top down' and 'bottom up' mode. In each region, young sudden death victims are registered and for all cases performance of autopsy and evaluation of relatives in a cardiogenetics outpatient clinic will be determined.Expected results. The study will provide information on the incidence of sudden death in the young and the proportion of diagnosed inherited cardiac diseases. Moreover, the additional value of the introduction of two different preventive strategies directed at early detection of inherited cardiac diseases in first-degree relatives to usual care will be evaluated. Conclusion. The CAREFUL study will help to set a new standard of care in the evaluation of young sudden death victims and their relatives to identify the presence of inherited cardiac diseases, in order to prevent sudden death. (Neth Heart J 2010;18:286-90.). Background . Sudden cardiac death (SCD) in the young (1-45 years) is a strong risk factor for the presence of inherited cardiac diseases in surviving first-degree relatives. Postmortem investigation of the victim and cardiogenetic evaluation of the first-degree relatives is indicated to detect inherited cardiac diseases and treat relatives at an early stage to prevent SCD. In the Netherlands, postmortem investigation is often not performed and relatives of SCD and sudden unexplained death (SUD) victims are rarely evaluated for inherited cardiac diseases. Methods . A prospective population-based follow-up study carried out in two intervention regions and two control regions. In the intervention regions a comprehensive intervention (stimulate autopsy and storage of victims DNA and the referral of first-degree relatives for cardiogenetic evaluation) is applied in a ‘top down’ and ‘bottom up’ mode. In each region, young sudden death victims are registered and for all cases performance of autopsy and evaluation of relatives in a cardiogenetics outpatient clinic will be determined. Expected results. The study will provide information on the incidence of sudden death in the young and the proportion of diagnosed inherited cardiac diseases. Moreover, the additional value of the introduction of two different preventive strategies directed at early detection of inherited cardiac diseases in first-degree relatives to usual care will be evaluated. Conclusion . The CAREFUL study will help to set a new standard of care in the evaluation of young sudden death victims and their relatives to identify the presence of inherited cardiac diseases, in order to prevent sudden death. ( Neth Heart J 2010; 18 : 286 –90. ) |
Author | Vink, A. van der Smagt, J. J. Hendrix, A. van Langen, I. M. Bots, M. L. Borleffs, C. J. W. Birnie, E. van der Werf, C. Wilde, A. A. M. van Weert, H. C. Mosterd, A. Doevendans, P. A. F. M. |
AuthorAffiliation | 12 Department of Clinical Genetics, Academic Medical Center, Amsterdam; Currently: Department of Clinical Genetics, Academic Medical Centre, Groningen, the Netherlands 7 Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands 5 Department of Clinical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands 10 Interuniversity Cardiology Institute of the Netherlands, Utrecht and Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands 2 Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands 6 Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands 1 Interuniversity Cardiology Institute of the Netherlands, Utrecht and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands 9 Interuniversity Cardiology Institute of the Netherlands, Utrecht and Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands 4 |
AuthorAffiliation_xml | – name: 2 Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands – name: 9 Interuniversity Cardiology Institute of the Netherlands, Utrecht and Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands – name: 1 Interuniversity Cardiology Institute of the Netherlands, Utrecht and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands – name: 10 Interuniversity Cardiology Institute of the Netherlands, Utrecht and Department of Cardiology, Academic Medical Center, Amsterdam, the Netherlands – name: 7 Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands – name: 3 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands – name: 4 Institute of Health Policy and Management, Erasmus Medical Center, Rotterdam, the Netherlands – name: 8 Department of General Practice, Academic Medical Center, Amsterdam, the Netherlands – name: 11 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Departments of Cardiology, University Medical Center Utrecht, Utrecht, and Meander Medical Center, Amersfoort, the Netherlands – name: 12 Department of Clinical Genetics, Academic Medical Center, Amsterdam; Currently: Department of Clinical Genetics, Academic Medical Centre, Groningen, the Netherlands – name: 5 Department of Clinical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands – name: 6 Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands |
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Snippet | Background. Sudden cardiac death (SCD) in the young (1-45 years) is a strong risk factor for the presence of inherited cardiac diseases in surviving... Background . Sudden cardiac death (SCD) in the young (1-45 years) is a strong risk factor for the presence of inherited cardiac diseases in surviving... |
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Subtitle | The yield of CARdiogenetic scrEening in First degree relatives of sudden cardiac and UnexpLained death victims <45 years |
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Title | Rationale and design of the CAREFUL study |
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