Obstructive Sleep Apnea and Heart Failure: Pathophysiologic and Therapeutic Implications

• Published in: Journal of the American College of Cardiology Vol. 57; no. 2; pp. 119 - 127
• Main Authors: KASAI, Takatoshi, BRADLEY, T. Douglas
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier 11.01.2011; Elsevier Limited
• Subjects: Biological and medical sciences; Cardiology; Cardiology. Vascular system; Disease Progression; Heart; Heart failure; Heart Failure - etiology; Heart Failure - physiopathology; Heart Failure - prevention & control; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Humans; Legs; Medical sciences; Morbidity; Mortality; Myocardial Contraction - physiology; Pneumology; Positive-Pressure Respiration - methods; Respiratory system : syndromes and miscellaneous diseases; Sleep apnea; Sleep Apnea, Obstructive - complications; Sleep Apnea, Obstructive - physiopathology; Sleep Apnea, Obstructive - therapy; Sleep disorders; Sympathetic Nervous System - physiopathology; Systole; Ventricular Function, Left; Heart failure; Nervous system diseases; Sleep apnea syndrome; Treatment; Respiratory disease; Heart disease; Cardiovascular disease; Circulatory system; Cardiology

Obstructive sleep apnea (OSA) exposes the cardiovascular system to intermittent hypoxia, oxidative stress, systemic inflammation, exaggerated negative intrathoracic pressure, sympathetic overactivation, and elevated blood pressure (BP). These can impair myocardial contractility and cause development...